Trends in cervical cancer incidence rates by age, race/ethnicity, histological subtype, and stage at diagnosis in the United States
Trends in cervical cancer incidence rates by age, race/ethnicity, histological subtype, and stage at diagnosis in the United States
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DOI：
10.1016/j.ypmed.2019.04.010
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发表时间：
2019-06-01
影响因子：
5.1
通讯作者：
Jemal, Ahmedin
中科院分区：
文献类型：
--
作者：
Islami, Farhad;Fedewa, Stacey A.;Jemal, Ahmedin
最近宫颈癌发病率的趋势，按组织学和年龄在美国（美国）没有报道。我们研究了美国宫颈鳞状细胞癌（SCC）和腺癌（AC）发病率在考虑子宫切除术后按年龄组、种族/民族和诊断阶段的当代趋势。发病率数据（1999-2015）来自美国癌症统计发病率分析数据库。使用国家健康访谈调查数据（2000-2015年）估计子宫切除术的患病率。除非西班牙裔白人外，所有种族/族裔群体的总体SCC发病率持续下降，非西班牙裔白人的发病率在2010年代趋于稳定，这主要是由于年龄< 50岁的趋势稳定，50-59岁的下降速度较慢。在1999年至2002年的稳定趋势之后，2002年至2015年非西班牙裔白人的AC发病率上升（每年1.3%），主要是由于40-49岁（自2004年以来每年4.4%）和50-59岁（自2011年以来每年5.5%）的增加。1999-2015年，黑人和西班牙裔的总体AC发病率下降，但在亚洲/太平洋岛民中保持稳定；在所有这些种族/民族中，发病率在年龄< 50岁时总体稳定，但在年龄较大时下降。在非西班牙裔白人中，远期宫颈SCC和AC的发病率在几个年龄组中有所增加，但在非白人中总体稳定。在几个亚群中，AC发病率的上升或稳定趋势以及SCC早期下降的减弱强调了加强努力扭转上升趋势和进一步减轻美国宫颈癌负担的重要性
Recent trends of cervical cancer incidence by histology and age in the United States (U.S.) have not been reported. We examined contemporary trends in cervical squamous cell carcinoma (SCC) and adenocarcinoma (AC) incidence rates in the U.S. by age group, race/ethnicity, and stage at diagnosis after accounting for hysterectomy. Incidence data (1999-2015) were obtained from the U.S. Cancer Statistics Incidence Analytic Database. Hysterectomy prevalence was estimated using National Health Interview Survey data (2000-2015). Overall SCC incidence rates continued to decrease in all racial/ethnic groups except among non-Hispanic whites in whom rates stabilized in the 2010s, largely driven by stable trends in ages < 50 years and a slower pace of decrease in ages 50-59 years. After a stable trend between 1999 and 2002, AC incidence rates among non-Hispanic whites rose during 2002-2015 (1.3% per year), mostly due to increases in ages 40-49 (4.4% annually since 2004) and 50-59 years (5.5% annually since 2011). Overall AC incidence rates during 1999-2015 decreased in blacks and Hispanics but were stable in Asian/Pacific Islanders; in all these race/ethnicities, rates were generally stable in ages < 50 years but decreasing in older ages. Rates of distant stage cervical SCC and AC among non-Hispanic whites increased in several age groups but were generally stable in non-whites. Increasing or stabilized incidence trends for AC and attenuation of earlier declines for SCC in several subpopulations underscore the importance of intensifying efforts to reverse the increasing trends and further reduce the burden of cervical cancer in the U.S.