Making the clock tick: the transcriptional landscape of the plant circadian clock.
Making the clock tick: the transcriptional landscape of the plant circadian clock.
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DOI：
10.12688/f1000research.11319.1
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Davis SJ
中科院分区：
文献类型：
--
作者：
Ronald J;Davis SJ
生物钟是一种分子计时器，通过整合光和温度刺激，使内部生理过程与外部环境同步。与其他真核生物一样，植物的昼夜节律主要由一系列核转录调控因子和相关的协同调控因子产生，这些调控因子被排列成一系列相互关联的分子环。这些转录调节因子利用染色质修饰酶来调节核小体的结构，从而促进或抑制DNA的可及性，从而指导转录速率。在这篇综述中，我们讨论了在了解拟南芥振荡器的结构和染色质动力学方面取得的最新进展，这些染色质动力学在生物钟内调节基因表达的节律模式的产生。
Circadian clocks are molecular timekeepers that synchronise internal physiological processes with the external environment by integrating light and temperature stimuli. As in other eukaryotic organisms, circadian rhythms in plants are largely generated by an array of nuclear transcriptional regulators and associated co-regulators that are arranged into a series of interconnected molecular loops. These transcriptional regulators recruit chromatin-modifying enzymes that adjust the structure of the nucleosome to promote or inhibit DNA accessibility and thus guide transcription rates. In this review, we discuss the recent advances made in understanding the architecture of the Arabidopsis oscillator and the chromatin dynamics that regulate the generation of rhythmic patterns of gene expression within the circadian clock.