Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use
Interactive effects of the serotonin transporter 5-HTTLPR polymorphism and stressful life events on college student drinking and drug use
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DOI：
10.1016/j.biopsych.2006.05.018
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发表时间：
2007-03-01
影响因子：
10.6
通讯作者：
Kranzler, Henry R.
中科院分区：
文献类型：
--
作者：
Covault, Jonathan;Tennen, Howard;Kranzler, Henry R.
背景：5-羟色胺转运体基因中一种常见的功能多态性5-HTTLPR与大学生大量饮酒有关。我们研究了这种多态性，因为它与负性生活事件相互作用，以预测饮酒和药物使用在大学生。方法：饮酒和药物使用的日常报告，使用每日网络调查获得的过去一年的负性生活事件和5-HTTLPR基因型的自我报告相结合，在酒精和非处方药使用的回归分析样本的295名大学生。结果：基因型和负性生活事件显着相互作用的饮酒和药物使用的结果。在前一年经历过多次负性生活事件的短（s）等位基因纯合子个体报告更频繁地饮酒和大量饮酒，更强烈的饮酒意图和更多的非处方药物使用。在长（1）等位基因纯合子的个体中，饮酒和吸毒不受过去一年负面生活事件的影响。杂合子受试者表现出饮酒的结果是中间的两个纯合子groups.Conclusions：5-HTTLPR的S-等位基因与增加饮酒和药物使用的大学生谁经历了多个负性生活事件。s-等位基因携带者可能在应对压力时有各种不良行为结果的风险。
Background: A common functional polymorphism, 5-HTTLPR, in the serotonin transporter gene has been associated with heavy drinking in college students. We examined this polymorphism as it interacted with negative life events to predict drinking and drug use in college students.Methods: Daily reports of drinking and drug use obtained using a daily web-based survey were combined with self-reports of past-year negative life events and 5-HTTLPR genotypes in a regression analysis of alcohol and nonprescribed drug use in a sample of 295 college students.Results: Genotype and negative life events significantly interacted in relation to drinking and drug use outcomes. Individuals homozygous for the short (s) allele who experienced multiple negative life events in the prior year reported more frequent drinking and heavy drinking, stronger intentions to drink, and greater nonprescribed drug use. In individuals homozygous for the long (1) allele, drinking and drug use were unaffected by past-year negative life events. Heterozygous subjects showed drinking outcomes that were intermediate to the two homozygous groups.Conclusions: The 5-HTTLPR s-allele is associated with increased drinking and drug use among college students who have experienced multiple negative life events. The s-allele carriers may be at risk for a variety of adverse behavioral outcomes in response to stress.