Eicosanoids in regulation of arterial smooth muscle cell phenotype, proliferative capacity, and cholesterol metabolism.
Eicosanoids in regulation of arterial smooth muscle cell phenotype, proliferative capacity, and cholesterol metabolism.
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类二十烷酸调节动脉平滑肌细胞表型、增殖能力和胆固醇代谢。
DOI：
10.1161/01.atv.9.4.413
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Hajjar,DP
中科院分区：
文献类型：
--
作者：
Pomerantz,KB;Hajjar,DP
从血小板-血管壁相互作用的角度来看，类二十烷酸，特别是前列环素（PGI 2）和血栓烷A2（TxA 2）参与了血管稳态的调节，并参与了血管张力和止血的调节（综述见参考文献1和2）。然而，随后的研究表明，PGI 2和其他类花生酸也可能在动脉平滑肌细胞表型和细胞胆固醇代谢的调节中发挥重要作用。这篇综述的目的是总结最近的研究结果的作用，类花生酸在正常生理条件下的平滑肌细胞的增殖能力和细胞胆固醇含量的调节和“致动脉粥样硬化”的环境。
Eicosanoids, particularly prostacyclin (PGI2) and throm-boxane A2 (TxA2), have been implicated in the regulation of vascular homeostasis from the point of view of platelet-vessel wall interactions and in the regulation of blood vessel tone and hemostasis (for reviews, see references 1 and 2). However, subsequent investigations have revealed that PGI2 and other eicosanoids may also have an important role in the regulation of arterial smooth muscle cell phenotype and cellular cholesterol metabolism. The purpose of this review is to summarize recent findings on the role of eicosanoids in the regulation of smooth muscle cell proliferative capacity and cellular cholesterol content under normal physiological conditions and in an" atherogenic" environment.