Echocardiographic Assessment of Cardiac Anatomy and Function in Hypertensive Subjects
Echocardiographic Assessment of Cardiac Anatomy and Function in Hypertensive Subjects
复制标题
高血压患者心脏解剖结构和功能的超声心动图评估
DOI：
10.1161/01.cir.59.4.623
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发表时间：
1979
期刊：
影响因子：
37.8
通讯作者：
J. Laragh
中科院分区：
文献类型：
--
作者：
D. Savage;J. Drayer;W. Henry;E. Mathews;J. Ware;J. Gardin;E. R. Cohen;S. Epstein;J. Laragh
心血管并发症是高血压患者发病率和死亡率的主要来源。为了评估此类患者心脏解剖和功能异常的发生率，我们通过超声心动图对234名无症状的轻中度系统性高血压患者进行了研究。在根据年龄和体表面积调整超声心动图的值后，我们发现61%的高血压受试者室间隔和/或后基底部游离壁厚度异常增加。我们发现5-7%的受试者左房、主动脉根部和左心室内径(舒张末)增大，6%和15%的受试者二尖瓣关闭速度(E-F斜率)和左心室射血分数降低。4%的患者有不成比例的室间隔增厚(即室间隔与左心室游离壁厚度比率>；1.3)。与超声心动图检测到的心脏异常的高发生率相反，高血压患者中只有不到10%的人有异常的12导联心电图或异常的胸部X光。这些发现表明，在无症状高血压受试者中，心脏异常的发生率很高。这些异常可以在超声心动图表现出来之前就被检测出来。
Cardiovascular complications are a major source of morbidity and mortality in hypertensive patients. To assess the prevalence of anatomic and functional abnormalities of the heart in such patients, we studied 234 asymptomatic subjects with mild-to-moderate systemic hypertension by echocardiography. After adjusting the echocardiographic values for age and body surface area, we found abnormally increased ventricular septal and/or posterobasal free-wall thickness in 61% of the hypertensive subjects. We found increased left atrial, aortic root, and left ventricular internal dimension (at end-diastole) in 5-7%, and decreased mitral valve closing velocity (E-F slope) and left ventricular ejection fraction were noted in six and 15% of the subjects, respectively. Four percent of the patients had disproportionate septal thickening (i.e., ventricular septal-to-left ventricular free-wall thickness ratio > 1.3). In contrast to the high prevalence of cardiac abnormalities detected by echocardiography, less than 10% of the hypertensive subjects had abnormal 12-lead ECGs or abnormal chest x-rays. These findings demonstrate a high prevalence of cardiac abnormalities in a population of asymptomatic hypertensive subjects. These abnormalities can be detected by echocardiography before they are otherwise apparent