Synthesis of biologically derived poly(pyrogallol) nanofibers for antibacterial applications.
Synthesis of biologically derived poly(pyrogallol) nanofibers for antibacterial applications.
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用于抗菌应用的生物衍生聚（连苯三酚）纳米纤维的合成。
DOI：
10.1039/d3tb00312d
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Kim,YoungJo
中科院分区：
文献类型：
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作者：
Tian,Zhen;Wu,Guo;Libby,Matt;Wu,Kang;Jeong,KyungJae;Kim,YoungJo
在此，我们介绍了聚（连苯三酚）生物聚合物的简便合成及其作为抗菌剂的应用。连苯三酚是一类酚类化合物，存在于多种植物中。聚合反应是通过连苯三酚在水合条件下的自动氧化来进行的。聚邻苯三酚的显微图像显示出高度均匀的纳米纤维结构，直径为 100.3 ± 16.3 nm。通过 FT-IR 光谱、拉曼光谱和 XPS 进行的光谱分析证实了聚合过程中邻苯三酚的羟基和相邻碳之间形成了醚 (C-O-C) 键。 FT-IR 和 XPS 光谱还揭示了聚（连苯三酚）纳米纤维上的氧化还原活性没食子官能团，可用于在氧化过程中释放自由电子和质子，然后生成活性氧（ROS）。聚焦三酚产生的ROS用于抑制细菌大肠杆菌的生长，在0.5小时和2小时内抑制率分别为56.3±9.7%和95.5±2.0%。这一发现表明，聚邻苯三酚可作为天然抗菌剂用于各种生物医学和环境应用。
Herein, we present the facile synthesis of poly(pyrogallol) biopolymers and their application as antibacterial agents. Pyrogallol is a class of phenolic compounds that can be found in various plants. Polymerization was performed by the auto-oxidation of pyrogallol under a hydrated condition. The microscopic image of poly(pyrogallol) shows a highly homogenous nanofibrous structure with a diameter of 100.3 ± 16.3 nm. Spectroscopic analysis by FT-IR spectroscopy, Raman spectroscopy, and XPS corroborated the formation of ether (C–O–C) bonds between the hydroxyl group and adjacent carbons of pyrogallol during polymerization. The FT-IR and XPS spectra also revealed redox-active gallol functional groups on poly(pyrogallol) nanofibers, which can be used to release free electrons and protons during oxidation followed by the generation of reactive oxygen species (ROS). The generated ROS from poly(pyrogallol) was used to inhibit the growth of bacteria, Escherichia coli, at a inhibition rates of 56.3 ± 9.7% and 95.5 ± 2.0% within 0.5 and 2 h, respectively. This finding suggests that poly(pyrogallol) can be used as a naturally occurring antibacterial agent for various biomedical and environmental applications.