Outcomes of immature oocytes collected from ovarian tissue for cryopreservation in adult and prepubertal patients
Outcomes of immature oocytes collected from ovarian tissue for cryopreservation in adult and prepubertal patients
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DOI：
10.1016/j.rbmo.2017.03.007
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发表时间：
2017-06-01
影响因子：
4
通讯作者：
Demeestere, Isabelle
中科院分区：
文献类型：
--
作者：
Fasano, Giovanna;Dechene, Julie;Demeestere, Isabelle
根据患者年龄、卵母细胞数量和组织运输条件，评估卵巢组织离体采集后卵母细胞体外成熟（IVM）和玻璃化处理的效率。136例患者接受了联合手术：130例成人（平均27.6 +/- 5.6岁）和6例青春期前女孩（平均8.7 +/- 2.3岁）。女孩的平均卵母细胞数（111.5 +/- 8.0）高于成人（3.8 +/- 4.2），P < 0.0011，但退化卵母细胞率（135.5%）高于成人（17.1%），P < 0.05
The efficiency of oocyte in-vitro maturation (IVM) and vitrification procedures after ex-vivo collection from ovarian tissue were assessed according to patient age, number of retrieved oocytes and tissue transport conditions. The combined procedure was performed in 136 patients: 130 adults (mean 27.6 +/- 5.6 years) and six prepubertal girls (mean 8.7 +/- 2.3 years). A higher mean number of oocytes were collected in girls compared with adults 111.5 +/- 8.0 versus 3.8 +/- 4.2, respectively, P < 0.0011 but the percentage of degenerated oocytes was significantly higher in girls 135.5% versus 17.1%, respectively, P