Relationship between visual field sensitivity and retinal nerve fiber layer thickness as measured by optical coherence tomography
Relationship between visual field sensitivity and retinal nerve fiber layer thickness as measured by optical coherence tomography
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DOI：
10.1167/iovs.06-0410
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发表时间：
2007-01-01
影响因子：
4.4
通讯作者：
Kovacs, Balint
中科院分区：
文献类型：
--
作者：
Ajtony, Csilla;Balla, Zsolt;Kovacs, Balint
目的.为了评价通过StratusOCT（Carl Zeiss Meditec，Inc.，都柏林，CA）。311名受试者-45名正常人，102名视野前青光眼（PPG）和164名原发性开角型青光眼（POAG）-被纳入这项横断面研究。用线性和非线性回归模型评价RNFL厚度与VF敏感性的关系，并计算决定系数（R-2）。RNFL/VF之间的关联用双变量Pearson相关系数来描述。正常眼和PPG眼RNFL与VF参数MS和MD的相关性不显著。在POAG眼，RNFL与MS（r = 0.733）和MD（r = 0.718）均显著相关。MS或MD对RNFL厚度的线性回归图表明，正常组（R-2分别为0.0378和0.0121）和PPG组（R-2分别为0.0215和0.0151）的决定程度可以忽略不计，而POAG组中它们的关系符合曲线回归模型（R-2 = 0.6947和0.723）。评价描述VF参数和平均RNFL厚度（AVG）的受试者工作特征（ROC）曲线，以区分PPG和POAG眼。重复分析最佳测试参数，模式标准差（PSD）（AUROC = 0.937），截止值为1.9 dB，结果显示PSD > 1.9 dB的POAG组的回归曲线保持了强的曲线RNFL/VF关系，而PSD > 1.9 dB的POAG组的回归曲线与PPG组几乎没有区别。对正常人和PPG或POAG患者结构-功能关系的评估显示，在PSD > 1.9 dB和RNFL AVG厚度低于70 μ m的POAG眼中，存在强烈的曲线回归，而在这些值以上则没有检测到相关性。
PURPOSE. To evaluate the strength and pattern of the relationship between visual field (VF) sensitivity and retinal nerve fiber layer (RNFL) thickness as measured by StratusOCT (Carl Zeiss Meditec, Inc., Dublin, CA).METHODS. Three hundred eleven subjects -45 normal, 102 with preperimetric glaucoma (PPG), and 164 with primary open-angle glaucoma (POAG)-were enrolled in this cross-sectional study. The relationship between RNFL thickness and VF sensitivity, expressed as mean deviation (MD) and mean sensitivity (MS), were evaluated with linear and nonlinear regression models, and the coefficient of determination (R-2) was calculated. The association between RNFL/VF was described by bivariate Pearson correlation coefficients.RESULTS. The correlation of RNFL and the VF parameters MS and MD in normal and PPG eyes was not significant. In POAG eyes, RNFL and both MS (r = 0.733) and MD (r = 0.718) correlated significantly. Linear regression plots of MS or MD against RNFL thickness demonstrated a negligible degree of determination in normal (R-2 = 0.0378 and 0.0121, respectively) and PPG groups (R-2 = 0.0215 and 0.0151, respectively), whereas their relationship fit a curvilinear regression model (R-2 = 0.6947 and 0.723) in the POAG group. Receiver operating characteristic (ROC) curves describing the VF parameters and average RNFL thickness (AVG) were evaluated to differentiate PPG from POAG eyes. Repeated analysis with the best-performing test parameter, pattern standard deviation (PSD) (AUROC = 0.937) with a cutoff of 1.9 dB, showed that regression profiles in the POAG group with PSD > 1.9 dB maintained a strong curvilinear RNFL/VF relationship, whereas those with PSD > 1.9 dB exhibited a relationship almost indistinguishable from the PPG group.CONCLUSIONS. Evaluation of the structure-function relationship in normal subjects and those with PPG or POAG showed strong curvilinear regression in POAG eyes with PSD > 1.9 dB and RNFL AVG thickness below 70 mu m, whereas no correlation was detectable above these values.