Tryptase as an inflammatory marker in allergic disease and asthma.
Tryptase as an inflammatory marker in allergic disease and asthma.
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DOI：
10.1586/1744666x.1.1.63
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发表时间：
2005-05-01
影响因子：
4.4
通讯作者：
Levi-Schaffer, Francesca
中科院分区：
文献类型：
--
作者：
Bachelet, Ido;Munitz, Ariel;Levi-Schaffer, Francesca
哮喘是一种慢性呼吸道炎症性疾病，从偶尔的喘息和呼吸短促到一种不可逆转的、危及生命的阻塞性疾病。虽然许多病例得到了相对轻松的处理，但其他病例对传统的吸入疗法甚至口服糖皮质激素没有反应。虽然哮喘目前还不能治愈，但如果诊断得当，它是可以控制的。通常，功能性临床参数是估计疾病严重程度的基础。此外，不断增长的细胞因子和介质分布数据库使它们能够被用作哮喘呼吸道炎症过程的分子标志物。类胰蛋白酶在过敏性炎症中是一种有效和多功能的介质，通过作用于大量的细胞和组织成分来协调急性和慢性事件。十多年来，类胰蛋白酶一直被用作哮喘和其他各种呼吸道疾病的过敏性炎症的标志物。在这篇综述中，将讨论目前使用类胰蛋白酶作为哮喘炎症标志物的优点和缺点。
Asthma is a chronic inflammatory disease of the airways, varying from occasional episodes of wheezing and shortness of breath, to an irreversible, life-threatening obstructive disease. While many cases are managed with relative ease, others do not respond to the traditional inhaled therapy or even to oral glucocorticosteroids. Although it cannot be cured as yet, asthma can be controlled if properly diagnosed. Usually, functional clinical parameters form the basis for estimation of the disease severity. In addition, the growing database of cytokine and mediator profiles have allowed their exploitation as molecular markers for processes underlying airway inflammation in asthma. Tryptase is a potent and versatile mediator in allergic inflammation, orchestrating both acute and chronic events by acting on a vast array of cells and tissue components. For more than a decade, tryptase has been used as a marker for allergic inflammation in asthma as well as in a variety of other airway diseases. In this review, the current advantages and disadvantages of the use of tryptase as an inflammatory marker in asthma will be discussed.