Physicochemical Characterization of Biomaterials Commonly Used in Dentistry as Bone Substitutes-Comparison with Human Bone
Physicochemical Characterization of Biomaterials Commonly Used in Dentistry as Bone Substitutes-Comparison with Human Bone
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DOI：
10.1002/jbm.b.31529
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发表时间：
2010-02-01
影响因子：
3.4
通讯作者：
Figueiredo, Helena
中科院分区：
文献类型：
--
作者：
Figueiredo, Margarida;Henriques, Jose;Figueiredo, Helena
目前的工作重点是选择的矿物基生物材料的物理化学特性，经常用于牙科应用。所选择的材料是商业上可获得的颗粒，来自不同的生物来源：牛，猪和珊瑚。自然和煅烧的人骨被用于比较目的。除了化学成分和结晶度的经典合理化之外，主要的重点放在各种形态结构特性的测量上，如粒度、孔隙度、密度和比表面积。这些特性对于获得对体内性能的全面解释至关重要。所研究的样品具有不同的颗粒大小（200至1000 μ m）和形状。汞侵入不仅表明样品的总孔隙度变化很大(OsteoBiol (R)为33%，PepGen P-15 (R)为50%，BioOss (R)为60%)，而且这些孔隙度中有很大一部分对应于亚微米孔隙。由于Biocoral (R)具有比孔隙度计上限更大的孔隙，因此该技术未对其进行分析。煅烧样品的密度值与羟基磷灰石的理论值接近。然而，胶原样品的数值较低，这与它们较低的矿物质含量有关。比表面积范围从小于1 m(2)/g （Biocoral）到60 m(2)/g （BioOss）。除文石外，大部分样品的化学和物相组成均以羟基磷灰石为主。尽管如此，由于每个样品都接受了不同的热处理，因此样品显示出不同的有机物质含量。(C) 2009 Wiley期刊公司[J] .中国生物医学工程学报，2016,31 (2):559 - 559
The present work focuses on the physicochemical characterization of selected mineral-based biomaterials that are frequently used in dental applications. The selected materials are commercially available as granules from different biological origins: bovine, porcine, and coralline. Natural and calcined human bone were used for comparison purposes. Besides a classical rationalization of chemical composition and crystallinity, a major emphasis was placed on the measurement of various morphostructural properties such as particle size, porosity, density, and specific surface area. Such properties are crucial to acquiring a full interpretation of the in vivo performance. The studied samples exhibited distinct particle sizes (between 200 and 1000 mu m) and shapes. Mercury intrusion revealed not only that the total sample porosity varied considerably (33% for OsteoBiol (R), 50% for PepGen P-15 (R), and 60% for BioOss (R)) but also that a significant percentage of that porosity corresponded to submicron pores. Biocoral (R) was not analyzed by this technique as it possesses larger pores than those of the porosimeter upper limit. The density values determined for the calcined samples were close to the theoretical values of hydroxyapatite. However, the values for the collagenated samples were lower, in accordance with their lower mineral content. The specific surface areas ranged from less than 1 m(2)/g (Biocoral) up to 60 m(2)/g (BioOss). The chemical and phase composition of most of the samples, the exception being Biocoral (aragonite), were hydroxyapatite based. Nonetheless, the samples exhibited different organic material content as a consequence of the distinct heat treatments that each had received. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 92B: 409-419, 2010