Activity changes in early visual cortex reflect monkeys' percepts during binocular rivalry
Activity changes in early visual cortex reflect monkeys' percepts during binocular rivalry
复制标题
DOI：
10.1038/379549a0
复制
发表时间：
1996-02-08
期刊：
影响因子：
64.8
通讯作者：
Logothetis, NK
中科院分区：
文献类型：
--
作者：
Leopold, DA;Logothetis, NK
当两只眼睛看到不同的图像时，我们会经历双眼竞争，其中一只眼睛的视野占主导地位几秒钟，然后被另一只眼睛的视野所取代（1,2）。在没有任何刺激变化的情况下，是什么导致了这些知觉变化？我们之前的研究表明，猴子皮层MT区的一些神经元在运动竞争中表现出反映感知到的运动方向的活动变化(3)。为了确定感知相关的活动调节是否发生在其他视觉皮质区域，我们记录了V1， V2和V4的单个神经元，同时猴子报告了两个正交方向的竞争光栅的感知方向。许多细胞，尤其是V4，表现出与感知优势和抑制一种刺激相关的活动模式。大多数是定向的，从两只眼睛都能很好地驱动它们。以前有人认为双眼竞争涉及V1内单眼神经元之间的相互抑制（例如，参见文献4），但我们的结果不支持这一观点；相反，我们认为双眼竞争是通过视觉通路中多个层次的双眼神经元之间的相互作用而产生的，并且类似的机制可能是在观看模糊图像时发生的其他多稳定感知状态的基础。
WHEN the two eyes view dissimilar images, we experience binocular rivalry, in which one eye's view dominates for several seconds and is then replaced by that of the other eye(1,2). What causes these perceptual changes in the absence of any change in the stimulus? We showed previously that some neurons in monkey cortical area MT show changes in activity during motion rivalry that reflect the perceived direction of motion(3). To determine whether perception-related modulation of activity occurs in other visual cortical areas, we recorded from individual neurons in V1, V2 and V4 while monkeys reported the perceived orientation of rival gratings of two orthogonal orientations. Many cells, particularly in V4, showed patterns of activity that correlated with the perceptual dominance and suppression of one stimulus. The majority were orientation-selective and could be driven equally well from either eye. It has been previously suggested that binocular rivalry involves reciprocal inhibition between monocular neurons within V1 (for example, see ref, 4), but our results do not support this view; rather, we propose that binocular rivalry arises through interactions between binocular neurons at several levels in the visual pathways, and that similar mechanisms may underlie other multistable perceptual states that occur when viewing ambiguous images.