Structural dimorphism of bile salt/lecithin mixed micelles. A possible regulatory mechanism for cholesterol solubility in bile? X-ray structure analysis.
Structural dimorphism of bile salt/lecithin mixed micelles. A possible regulatory mechanism for cholesterol solubility in bile? X-ray structure analysis.
复制标题
胆盐/卵磷脂混合胶束的结构二态性。
DOI：
10.1021/bi00505a028
复制
发表时间：
1981
期刊：
影响因子：
2.9
通讯作者：
Müller,K
中科院分区：
文献类型：
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作者：
Müller,K
Karl Muller** 摘要：胆盐/卵磷脂混合胶束在0.15 M生理盐水的三维结构来自X射线小角散射测量在各种条件下。检测到两种基本上不同类型的胶束。胆盐：当卵磷脂的摩尔比小于2：1时，形成了类似于卵磷脂双层结构的层状颗粒，当卵磷脂的摩尔比为1：1时，卵磷脂双层的厚度为5.1nm。发现胶束的侧向尺寸强烈依赖于摩尔比，随着卵磷脂含量的增加而增加。此外，似乎在某些不完全限定的条件下，出现直径大于100 nm的泡状颗粒。这种类型的胶束的分子模型已被推导出通过一个彻底的解释的电子密度分布在整个平面的双层。该模型与Mazer等人的“混合盘”模型基本一致。[Mazer，NA，Kwasnick，RF，Carey，M.
Karl Muller** abstract: The three-dimensional structure of bile salt/lecithin mixed micelles in 0.15 M saline was derived from X-ray small-angle scattering measurements under various conditions. Two essentially different types of micelles were detected. At bile salt: lecithin molar ratios lower than approximately 2: 1, lamellar particles similar to a lecithin bilayer arrangement were found. The thickness of the bilayer is 5.1 nm for mixed mi-celles having a molar ratio of 1: 1. The lateral dimensions of the micelle were found strongly dependent upon molar ratio, increasing as lecithin content increases. In addition, it appeared that under certain incompletely defined conditions vesicular particles having diameters in the region of more than 100 nm occur. A molecular model of this type of micelle has been derived by means of a thorough interpretation of the electron density distribution across the plane of the bilayer. This model is generally consistent with the “mixed-disk” model of Mazer et al.[Mazer, NA, Kwasnick, RF, Carey, M.