WRAP53 is an independent prognostic factor in rectal cancer- a study of Swedish clinical trial of preoperative radiotherapy in rectal cancer patients.
WRAP53 is an independent prognostic factor in rectal cancer- a study of Swedish clinical trial of preoperative radiotherapy in rectal cancer patients.
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DOI：
10.1186/1471-2407-12-294
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发表时间：
2012-07-17
期刊：
影响因子：
3.8
通讯作者：
Sun XF
中科院分区：
文献类型：
--
作者：
Zhang H;Wang DW;Adell G;Sun XF
WRAP 53蛋白的表达具有致癌特性，并且在几种类型的肿瘤中上调。我们检测了WRAP 53蛋白在直肠癌中的表达，并分析了其与术前放疗反应和患者生存率的关系。WRAP 53蛋白通过免疫组化检测了143例直肠癌患者的正常粘膜、原发肿瘤和淋巴结转移，这些患者参加了瑞典的术前放疗临床试验。WRAP 53蛋白在原发性直肠癌中的表达频率高于正常黏膜（p < 0.05）。在非放疗组中，原发性肿瘤（p = 0.03，RR，3.73，95%CI，1.13-11.89）或转移瘤（p = 0.01，RR，4.11，95%CI，1.25-13.14）中WRAP 53阳性与预后不良相关，与分期和分化无关。在放疗组中，转移灶中WRAP 53阳性与更好的生存相关（p = 0.04）。交互作用分析显示，WRAP 53与放疗和非放疗转移的预后意义的相关性不同（p = 0.01）。在放疗组中，转移灶中WRAP 53的表达给出了更好的结果（p = 0.02，RR，0.32，95%CI，0.13-0.84），并且交互作用分析显示两组之间的显著性（p = 0.01）。WRAP 53可能成为一种新的生物标志物，用于预测预后和选择合适的患者进行术前放射治疗。
Expression of WRAP53 protein has oncogenic properties and it is up regulated in several types of tumors. We examined expression of WRAP53 protein in rectal cancers and analyzed its relationship to the response to preoperative radiotherapy and patient survival. The WRAP53 protein was examined by immunohistochemistry in normal mucosa, primary tumors and lymph node metastases from 143 rectal cancer patients participated in a Swedish clinical trial of preoperative radiotherapy. Frequency of WRAP53 protein expression was increased in primary rectal cancer compared to the normal mucosa (p < 0.05). In non-radiotherapy group positive WRAP53 in primary tumors (p = 0.03, RR, 3.73, 95% CI, 1.13-11.89) or metastases (p = 0.01, RR, 4.11, 95% CI, 1.25-13.14), was associated with poor prognosis independently of stages and differentiations. In radiotherapy group, positive WRAP53 in the metastasis correlated with better survival (p = 0.04). An interaction analysis showed that the correlations of WRAP53 with the prognostic significance with and without radiotherapy in the metastasis differed (p = 0.01). In the radiotherapy group, expression of WRAP53 in metastases gave a better outcome (p = 0.02, RR, 0.32, 95% CI, 0.13-0.84), and an interaction analysis showed significance between the two groups (p = 0.01). WRAP53 may be a new biomarker used to predict prognosis and to select suitable patients for preoperative radiotherapy.
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影响因子：
9.8
作者：
Mahmoudi S;Henriksson S;Weibrecht I;Smith S;Söderberg O;Strömblad S;Wiman KG;Farnebo M
通讯作者：
Farnebo M
影响因子：
158.5
作者：
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通讯作者：
van de Velde, CJH
影响因子：
9
作者：
通讯作者：
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影响因子：
8
作者：
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通讯作者：
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影响因子：
7.3
作者：
Koehler, A;Bataille, F;Dietmaier, W
通讯作者：
Dietmaier, W