18FDG-PET imaging and histopathology in neuroleukemiosis with acute myeloid leukemia
18FDG-PET imaging and histopathology in neuroleukemiosis with acute myeloid leukemia
复制标题
神经白血病合并急性髓系白血病的 18FDG-PET 成像和组织病理学
DOI：
10.1007/s12185-020-02976-w
复制
发表时间：
2020
影响因子：
2.1
通讯作者：
Nishikii Hidekazu
中科院分区：
文献类型：
--
作者：
Kiyoki Yusuke;Matsuoka Ryota;Kaneta Tomohiro;Nishikii Hidekazu
患者男，30岁，外周血有髓母细胞增多症，骨髓中有大量白血病母细胞渗入。流式细胞仪检测结果为CD7−CD11b+CD14−CD33+CD34−CD56+，过氧化物酶阳性，酯酶染色阴性。细胞遗传学分析显示了一种复杂的核型。他被诊断为急性髓系白血病，未成熟(FAB分类：AML-M1)。用伊达比星和阿糖胞苷缓解诱导化疗导致血液学完全缓解。然而，经过2个周期的巩固化疗后，白血病细胞出现了脑膜浸润。抢救化疗联合鞘内化疗，脑脊液中白血病细胞消失。尽管如此，患者仍主诉严重的外周神经痛。未检测到白血病细胞
A 30-year old man demonstrated myeloblastosis in the peripheral blood and massive infiltration of leukemic blasts in the bone marrow. The myeloblasts showed CD7− CD11b+ CD14− CD33+ CD34− CD56+ by flow cytometry, and positive peroxidase and negative esterase stainings. Cytogenetic analysis revealed a complex karyotype. He was diagnosed as acute myeloid leukemia, without maturation (FAB classification: AML-M1).Remission induction chemotherapy with idarubicin and cytarabine resulted in hematologic complete remission. However, meningeal infiltration of leukemic cells developed after 2 cycles of consolidation chemotherapy. Salvage chemotherapy together with intrathecal chemotherapy was administered, and leukemic cells in cerebrospinal fluid disappeared. Nonetheless, the patient complained severe peripheral neuralgia. No leukemic cells were detected in