Toxicity of the brominated flame retardant tris-(2,3-dibromopropyl) isocyanurate in zebrafish (Danio rerio)
Toxicity of the brominated flame retardant tris-(2,3-dibromopropyl) isocyanurate in zebrafish (Danio rerio)
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DOI：
10.1007/s11434-011-4471-6
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发表时间：
2011-04
影响因子：
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通讯作者：
X. Zhang;Juan Li;Minjie Chen;Le Wu;Chi Zhang;Jie Zhang;Qunfang Zhou;Yong Liang
中科院分区：
文献类型：
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作者：
X. Zhang;Juan Li;Minjie Chen;Le Wu;Chi Zhang;Jie Zhang;Qunfang Zhou;Yong Liang
Tris-(2,3-dibromopropyl) isocyanurate (TBC) is a heterocyclic brominated flame retardant that was recently detected in the environment in China. TBC is semi-volatile and can accumulate in the lipid of some species, but little is known about its effect on aquatic organisms. We exposed adult zebrafish to 0, 0.25, 1 and 4 mg/L TBC for 28 d and measured the effect on survival, growth, histopathology, hormone levels, enzyme activity, and gene expression. TBC exposure had no effect on survival or growth. We observed significant damage to the liver and gill, including hepatocellular swelling and fatty degeneration in the liver as well as proliferation and edema of epithelial cells in the gills. In addition, exposure to 4 mg/L TBC induced proliferation of goblet cells in the intestine of both sexes, acellular areas in the testis, and thinly scattered vitellogenic granules in vitellogenic oocytes. TBC exposure had no effect on the levels of thyroid hormones, testosterone, estradiol, liver superoxide dismutase activity, malondialdehyde content, and brain cholinesterase activity. By contrast, hepatic vitellogenin and cytochromeP4501Agene expression was significantly down-regulated in both male and female zebrafish in response to TBC exposure. Our results suggest that exposure to TBC causes a variety of potential reproductive and endocrine toxic effects.
