Identification of a novel role for Drosophila MESR4 in lipid metabolism
Identification of a novel role for Drosophila MESR4 in lipid metabolism
复制标题
果蝇 MESR4 在脂质代谢中的新作用的鉴定
DOI：
10.1111/gtc.12221
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发表时间：
2015
期刊：
影响因子：
2.1
通讯作者：
Tsuda M.

中科院分区：
文献类型：
--
作者：
Tsuda-Sakurai K;Seong KH;Horiuchi J;Aigaki T;Tsuda M.

果蝇为分析脂质代谢提供了一个强大的遗传模型。果蝇有一个类似脂肪的器官，称为脂肪体，它在能量稳态中起着至关重要的作用。在这里，我们进行了脂肪体特异性错误表达筛选，以确定参与脂质代谢的基因。我们发现，一种具有9个C2 H2型锌指基序和一个PHD-指的核蛋白，ras 4的错误表达抑制因子（MESR 4）的过表达，减少了脂肪体中的脂质积累，而MESR 4的敲低则增加了脂肪体中的脂质积累。我们进一步表明，MESR 4上调了主要脂肪酶的表达，这可能是脂肪体中脂质储存减少和体内游离脂肪酸（FFA）释放的原因。这些结果表明，MESR 4作为一个重要的上游调节能量稳态。
Drosophilaprovides a powerful genetic model to analyze lipid metabolism.Drosophilahas an adipose‐like organ called the fat body, which plays a crucial role in energy homeostasis. Here, we conducted a fat body‐specific misexpression screen to identify genes involved in lipid metabolism. We found that over‐expression of a nuclear protein with nine C2H2type zinc‐finger motifs and a PHD‐finger, Misexpression suppressor of ras 4 (MESR4), reduces lipid accumulation in the fat body, whereasMESR4knockdown increases it. We further show thatMESR4up‐regulates the expression of major lipases, which may account for the reduction in lipid storage in the fat body and the release of free fatty acids (FFAs) in the body. These results suggest that MESR4 acts as an important upstream regulator of energy homeostasis.