Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study.
Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study.
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DOI：
10.1038/ncomms8934
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发表时间：
2015-08-11
影响因子：
16.6
通讯作者：
McGorry PD
中科院分区：
文献类型：
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作者：
Amminger GP;Schäfer MR;Schlögelhofer M;Klier CM;McGorry PD
长链omega-3多不饱和脂肪酸（PUFA）对神经发育和功能至关重要。作为脑组织的关键成分，ω-3多不饱和脂肪酸在大脑发育和功能中起着关键作用，缺乏这些脂肪酸与一生中的许多精神健康状况有关，包括精神分裂症。我们之前已经证明，与安慰剂相比，使用omega-3 PUFA进行12周的干预可以降低患有阈下精神病状态的年轻人12个月内进展为精神障碍的风险。我们现在已经完成了这项随机、双盲、安慰剂对照试验的长期随访，中位随访时间为6.7年。在这里，我们表明，在这项研究中，ω-3多不饱和脂肪酸的短暂干预降低了进展为精神病性障碍和精神病发病率的风险。来自omega-3组的大多数个体没有表现出严重的功能障碍，并且在随访时不再经历减弱的精神病症状。 长链ω-3多不饱和脂肪酸对神经发育至关重要，缺乏这些脂肪酸与许多精神健康状况有关。在这里，作者报告了一项随机、双盲、安慰剂对照的临床试验的长期疗效，该试验评估了鱼油胶囊对精神病高危人群的影响。
Long-chain omega-3 polyunsaturated fatty acids (PUFAs) are essential for neural development and function. As key components of brain tissue, omega-3 PUFAs play critical roles in brain development and function, and a lack of these fatty acids has been implicated in a number of mental health conditions over the lifespan, including schizophrenia. We have previously shown that a 12-week intervention with omega-3 PUFAs reduced the risk of progression to psychotic disorder in young people with subthreshold psychotic states for a 12-month period compared with placebo. We have now completed a longer-term follow-up of this randomized, double-blind, placebo-controlled trial, at a median of 6.7 years. Here we show that brief intervention with omega-3 PUFAs reduced both the risk of progression to psychotic disorder and psychiatric morbidity in general in this study. The majority of the individuals from the omega-3 group did not show severe functional impairment and no longer experienced attenuated psychotic symptoms at follow-up. Long-chain omega-3 polyunsaturated fatty acids are essential for neural development and lack of these fatty acids has been implicated in a number of mental health conditions. Here the authors report the longer-term efficacy of a randomized, double-blind, placebo-controlled clinical trial assessing the effects of fish oil capsules in individuals at ultrahigh risk for psychosis.