Diffusion tensor MRI as a biomarker in axonal and myelin damage.
Diffusion tensor MRI as a biomarker in axonal and myelin damage.
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DOI：
10.2217/iim.13.49
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发表时间：
2013-10-01
期刊：
影响因子：
--
通讯作者：
Benzinger TL
中科院分区：
文献类型：
--
作者：
Aung WY;Mar S;Benzinger TL
弥散张量成像已被广泛用作研究工具，以了解与白质病理相关的结构变化。利用水扩散作为构造解剖细节的基础，扩散张量成像提供了在常规MRI上明显的大体解剖变化（如病变和肿瘤）之前识别结构和功能适应的潜力。在过去的10年里，进一步的参数，如轴向和径向扩散率，已经发展到表征特定于轴突和髓鞘的白质变化。本文就扩散张量成像定向扩散率作为神经系统疾病轴突和髓鞘损伤的生物标志物的潜在应用和有待解决的问题进行综述。
Diffusion tensor imaging has been used extensively as a research tool to understand the structural changes associated with white matter pathology. Using water diffusion as the basis to construct anatomic details, diffusion tensor imaging offers the potential to identify structural and functional adaptations before gross anatomical changes, such as lesions and tumors, become apparent on conventional MRI. Over the past 10 years, further parameters, such as axial and radial diffusivity, have been developed to characterize white matter changes specific to axons and myelin. In this paper, the potential application and outstanding issues on the use of diffusion tensor imaging directional diffusivity as a biomarker in axonal and myelin damage in neurological disorders will be reviewed.