Free radical scavenging ability and antioxidant efficiency of curcumin and its substituted analogue
Free radical scavenging ability and antioxidant efficiency of curcumin and its substituted analogue
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DOI：
10.1016/s0301-4622(99)00070-8
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发表时间：
1999-08-09
影响因子：
3.8
通讯作者：
Rao, MNA
中科院分区：
文献类型：
--
作者：
Khopde, SM;Priyadarsini, KI;Rao, MNA
姜黄素及其乙氧基取代衍生物 (C1) 1,7-双-(4-羟基-3-乙氧基苯基)-1,6-庚二烯-3,5-二酮的自由基反应已使用脉冲放射分解技术在均质水-有机溶液（如乙腈-水和异丙醇-水混合物）以及中性 TX-100 和阳离子 CTAB 胶束溶液中进行了研究。姜黄素或C1的苯氧基自由基是通过单电子转移到几种氧化剂如N-3(.)、Br-2(-.)、CCl3O2.、谷胱甘肽自由基而产生的，其在300-600 nm波长范围内表现出吸收，最大吸收波长为490-500 nm。苯氧基自由基的其他重要性质，如消光系数、自由基寿命及其形成和衰变速率常数也在这些系统中测定。姜黄素和 C1 的抗氧化特性根据其抑制脂质体中脂质过氧化的能力以及 trolox 当量抗氧化能力 (TEAC) 来评估。将结果与α-生育酚进行比较。 (C) 1999 Elsevier Science B.V. 保留所有权利。
Free radical reactions of curcumin and its ethoxy substituted derivative (C1) 1,7-bis-(4-hydroxy-3-ethoxy phenyl)-1,6-heptadiene-3,5-dione have been studied using a pulse radiolysis technique in homogeneous aqueous-organic solutions like acetonitrile-water and isopropanol-water mixtures, as well as in neutral TX-100 and cationic CTAB micellar solutions. The phenoxyl radicals of curcumin or C1 were generated by one-electron transfer to several oxidants like N-3(.), Br-2(-.), CCl3O2., glutathione radicals which exhibit absorption from a 300-600-nm wavelength region with the maximum at 490-500 nm. Other important properties of the phenoxyl radicals such as extinction coefficient, radical lifetime and their formation and decay rate constants were also determined in these systems. The antioxidant property of curcumin and C1 were estimated in terms of their ability to inhibit the lipid peroxidation in liposomes and also in terms of trolox equivalent antioxidant capacity (TEAC). The results were compared with alpha-tocopherol. (C) 1999 Elsevier Science B.V. All rights reserved.