Drosophila melanogaster recombination rate calculator
Drosophila melanogaster recombination rate calculator
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DOI：
10.1016/j.gene.2010.04.015
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发表时间：
2010-09-01
期刊：
影响因子：
3.5
通讯作者：
Petrov, Dmitri A.
中科院分区：
文献类型：
--
作者：
Fiston-Lavier, Anna-Sophie;Singh, Nadia D.;Petrov, Dmitri A.
重组率是决定位点连接程度的关键进化参数。因此，估计重组率对群体遗传和分子进化研究至关重要。我们在这里提出了一个用户友好的基于网络的工具，可以用来检索黑腹果蝇基因组中单个和/或多个位点的重组率估计，给定用户自定义的基因组释放选择。我们使用了基于比较遗传图谱和物理图谱的Marey图谱方法来推断D. melanogaster基因组主要染色体的重组率。我们的这种方法的实现是基于构建三阶多项式，用于插值染色体上所有点的重组率，除了端粒和着丝粒区域，其中这种多项式已知提供特别差的估计。Elsevier B.V.出版
Recombination rate is a key evolutionary parameter that determines the degree to which sites are linked. Estimating recombination rates is thus of crucial importance for population genetic and molecular evolutionary studies. We present here a user-friendly web-based tool that can be used to retrieve recombination rate estimates for single and/or multiple loci in the Drosophila melanogaster genome given a user-defined choice of the genome release. We used the Marey map approach that is based on comparing the genetic and physical maps to infer recombination rates along the major chromosomes of the D. melanogaster genome. Our implementation of this approach is based on building third-order polynomials which are used to interpolate recombination rates at all points on the chromosome except for telomeric and centromeric regions in which such polynomials are known to provide particularly poor estimation. Published by Elsevier B.V.