No accelerated rate of protein evolution in male-biased Drosophila pseudoobscura genes
No accelerated rate of protein evolution in male-biased Drosophila pseudoobscura genes
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DOI：
10.1534/genetics.106.057414
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发表时间：
2006-09-01
期刊：
影响因子：
3.3
通讯作者：
Schlotterer, Christian
中科院分区：
文献类型：
--
作者：
Metta, Muralidhar;Gudavalli, Rambabu;Schlotterer, Christian
性二型特征通常会受到多样化选择的影响。男性偏向基因表达的基因也可能受到性别选择的影响，并具有较高的蛋白质进化速度。我们使用SAGE来测量果蝇性别偏见基因的表达。与之前的研究结果一致，更多的基因偏向于男性(402个基因)而不是偏向女性(138个基因)。大约34%的基因改变了黑腹毛虫和假黑腹毛虫之间与性别相关的表达模式。结合两个物种之间的基因表达和蛋白质差异，我们观察到只有一个物种中具有男性偏向基因表达的基因的进化速度存在显著差异。与预期相反的是，这一类别中的假黑丝虫基因没有显示出蛋白质进化的加速速度，而黑腹丝虫基因则显示出了加速的蛋白质进化速度。如果说性别选择推动了男性偏向基因的分子进化，那么我们的数据暗示了假黑斑潜蝇一种截然不同的选择机制。
Sexually dimorphic traits are often subject to diversifying selection. Genes with a male-biased gene expression also are probably affected by sexual selection and have a high rate of protein evolution. We used SAGE to measure sex-biased gene expression in Drosophila pseudoobscura. Consistent with previous results from D. melanogaster, a larger number of genes were male biased (402 genes) than female biased (138 genes). About 34% of the genes changed the sex-related expression pattern between D. melanogaster and D. pseudoobscura. Combining gene expression with protein divergence between both species, we observed a striking difference in the rate of evolution for genes with a male-biased gene expression in one species only. Contrary to expectations, D. pseudoobscura genes in this category showed no accelerated rate of protein evolution, while D. melanogaster genes did. If sexual selection is driving molecular evolution of male-biased genes, our data imply a radically different selection regime in D. pseudoobscura.