Association of sarcopenia with performance in multiple cognitive domains: results from the ELSA-Brasil study.
Association of sarcopenia with performance in multiple cognitive domains: results from the ELSA-Brasil study.
复制标题
肌肉减少症与多个认知领域表现的关联：ELSA-巴西研究的结果。
DOI：
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复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
I. Benseñor
中科院分区：
文献类型：
--
作者：
C. Szlejf;C. Suemoto;P. Lotufo;I. Benseñor
背景
和认知障碍有着共同的病理生理学途径和危险因素。我们的目的是调查肌肉减少症及其定义成分与中老年人认知能力的关系。
方法
这项横断面分析包括来自ELSA-巴西研究的5038名年龄≥ 55岁的参与者。通过生物电阻抗分析评估肌肉质量，通过握力评估肌肉力量。根据美国国立卫生研究院基金会定义肌肉减少症。认知能力采用延迟单词回忆测试、语义语言流畅性测试和连线测试B进行评估。可能的混杂因素包括社会人口统计学特征、生活方式和临床合并症。
结果
肌肉减少症、肌肉质量降低和肌肉力量降低的频率分别为1.8%、23.3%和4.4%。调整可能的混杂因素后，言语流畅性测试的较差表现与肌肉减少症（β =-0.20，95% CI = -0.38;-0.01，p = 0.03）和低肌肉质量（β =-0.08，95% CI = -0.14;-0.01，p = 0.02）相关。肌肉力量低与延迟单词回忆测试中的表现较差有关（β =-0.14，95%CI = -0.27;-0.02，p = 0.02），语言流畅性测试（β =-0.14，95%CI = -0.26;-0.02，p = 0.03），连线检验（β =-0.15，95%CI = -0.27;-0.03，p = 0.01）。
结论
肌肉减少症与语言流畅性测试中的表现较差相关，而肌肉力量不足与中老年人所有认知测试中的表现较差相关。
BACKGROUND
and cognitive impairment share pathophysiological paths and risk factors. Our aim was to investigate the association of sarcopenia and its defining components with cognitive performance in middle-aged and older adults.
METHODS
This cross-sectional analysis included 5038 participants from the ELSA-Brasil Study, aged ≥ 55 years. Muscle mass was evaluated by bioelectrical impedance analysis and muscle strength by handgrip strength. Sarcopenia was defined according to the Foundation for the National Institutes of Health. Cognition was evaluated using delayed word recall test, semantic verbal fluency test, and trail making test B. Possible confounders included socio-demographic characteristics, lifestyle, and clinical comorbidities.
RESULTS
The frequencies of sarcopenia, low muscle mass, and low muscle strength were 1.8%, 23.3%, and 4.4%, respectively. After adjustment for possible confounders, poorer performance on the verbal fluency test was associated with sarcopenia (β = -0.20, 95% CI = -0.38; -0.01, p = 0.03) and low muscle mass (β = -0.08, 95% CI = -0.14; -0.01, p = 0.02). Low muscle strength was associated with poorer performance in the delayed word recall test (β = -0.14, 95% CI = -0.27; -0.02, p = 0.02), verbal fluency test (β = -0.14, 95% CI = -0.26; -0.02, p = 0.03), and trail making test (β = -0.15, 95% CI = -0.27; -0.03, p = 0.01).
CONCLUSIONS
Sarcopenia was associated with poorer performance on the verbal fluency test and low muscle strength was associated with poorer performance in all cognitive tests in middle-aged and older adults.
DOI：
10.1093/gerona/gls191
发表时间：
2013-04-01
影响因子：
5.1
作者：
Verghese, Joe;Wang, Cuiling;Holtzer, Roee
通讯作者：
Holtzer, Roee