Two loci on chromosome 5 are associated with serum IgE levels in Labrador retrievers.
Two loci on chromosome 5 are associated with serum IgE levels in Labrador retrievers.
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5 号染色体上的两个位点与拉布拉多猎犬的血清 IgE 水平相关。
DOI：
10.1371/journal.pone.0039176
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Leeb T
中科院分区：
文献类型：
--
作者：
Owczarek-Lipska M;Lauber B;Molitor V;Meury S;Kierczak M;Tengvall K;Webster MT;Jagannathan V;Schlotter Y;Willemse T;Hendricks A;Bergvall K;Hedhammar A;Andersson G;Lindblad-Toh K;Favrot C;Roosje P;Marti E;Leeb T
Crosslinking of immunoglobulin E antibodies (IgE) bound at the surface of mast cells and subsequent mediator release is considered the most important trigger for allergic reactions. Therefore, the genetic control of IgE levels is studied in the context of allergic diseases, such as asthma, atopic rhinitis, or atopic dermatitis (AD). We performed genome-wide association studies in 161 Labrador Retrievers with regard to total and allergen-specific immunoglobulin E (IgE) levels. We identified a genome-wide significant association on CFA 5 with the antigen-specific IgE responsiveness to Acarus siro. We detected a second genome-wide significant association with respect to the antigen-specific IgE responsiveness to Tyrophagus putrescentiae at a different locus on chromosome 5. A. siro and T. putrescentiae both belong to the family Acaridae and represent so-called storage or forage mites. These forage mites are discussed as major allergen sources in canine AD. No obvious candidate gene for the regulation of IgE levels is located under the two association signals. Therefore our studies offer a chance of identifying a novel mechanism controlling the host's IgE response.
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影响因子：
2.8
作者：
deWeck, AL;Mayer, P;Pickart, L
通讯作者：
Pickart, L
影响因子：
2.4
作者：
MAZZA, G;WHITING, AH;DUFFUS, WPH
通讯作者：
DUFFUS, WPH
DOI：
10.1016/j.jaci.2011.09.029
发表时间：
2012-03
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Granada M;Wilk JB;Tuzova M;Strachan DP;Weidinger S;Albrecht E;Gieger C;Heinrich J;Himes BE;Hunninghake GM;Celedón JC;Weiss ST;Cruikshank WW;Farrer LA;Center DM;O'Connor GT
通讯作者：
O'Connor GT
影响因子：
1.8
作者：
DeBoer, DJ;Hillier, A
通讯作者：
Hillier, A
影响因子：
2.7
作者：
Jackola, Duaine R.;Miller, Michael B.;Blumenthal, Malcolm N.
通讯作者：
Blumenthal, Malcolm N.