The fission yeast Schizosaccharomyces pombe as a model to understand how peroxiredoxins influence cell responses to hydrogen peroxide.
The fission yeast Schizosaccharomyces pombe as a model to understand how peroxiredoxins influence cell responses to hydrogen peroxide.
复制标题
以裂殖酵母粟酒裂殖酵母为模型，了解过氧化还原蛋白如何影响细胞对过氧化氢的反应。
DOI：
10.1042/bst20140059
复制
发表时间：
2014
影响因子：
3.9
通讯作者：
Veal EA
中科院分区：
文献类型：
--
作者：
Veal EA
作为一种更具选择性的活性氧，H2 O2（过氧化氢）已被选为信号分子，但高水平仍然会导致致命的细胞损伤。2-Cys Prxs（peroxiredoxins）是普遍存在的硫氧还蛋白过氧化物酶，其利用可逆氧化的催化半胱氨酸残基来还原过氧化物。因此，Prxs可能对抗氧化损伤的细胞防御库做出重要贡献。虽然真核生物2-Cys Prxs的丰度表明在维持细胞氧化还原中的重要作用，但其硫氧还蛋白过氧化物酶活性对H2 O2失活的惊人敏感性引起了人们对它们作为氧化应激防御的作用的质疑。事实上，在模型酵母中的工作已经揭示了Prxs不仅仅是简单地去除过氧化物，甚至发现了它们的硫氧还蛋白过氧化物酶活性是有害的情况。在本论文中，我们集中在我们所学到的研究在裂殖酵母裂殖酵母pombe的不同角色的2-Cys Prxs在响应H2 O2和讨论的一般影响，这些发现为其他系统。
As a more selectively reactive oxygen species, H2O2(hydrogen peroxide) has been co-opted as a signalling molecule, but high levels can still lead to lethal amounts of cell damage. 2-Cys Prxs (peroxiredoxins) are ubiquitous thioredoxin peroxidases which utilize reversibly oxidized catalytic cysteine residues to reduce peroxides. As such, Prxs potentially make an important contribution to the repertoire of cell defences against oxidative damage. Although the abundance of eukaryotic 2-Cys Prxs suggests an important role in maintaining cell redox, the surprising sensitivity of their thioredoxin peroxidase activity to inactivation by H2O2has raised questions as to their role as an oxidative stress defence. Indeed, work in model yeast has led the way in revealing that Prxs do much more than simply remove peroxides and have even uncovered circumstances where their thioredoxin peroxidase activity is detrimental. In the present paper, we focus on what we have learned from studies in the fission yeastSchizosaccharomyces pombeabout the different roles of 2-Cys Prxs in responses to H2O2and discuss the general implications of these findings for other systems.
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影响因子：
16
作者：
Day, Alison M.;Brown, Jonathon D.;Veal, Elizabeth A.
通讯作者：
Veal, Elizabeth A.
DOI：
10.1073/pnas.0805507105
发表时间：
2008-12-16
影响因子：
11.1
作者：
Olahova, Monika;Taylor, Sarah R.;Veal, Elizabeth A.
通讯作者：
Veal, Elizabeth A.
影响因子：
16
作者：
Veal, EA;Findlay, VJ;Morgan, BA
通讯作者：
Morgan, BA
影响因子：
3.9
作者：
Koo, KH;Lee, S;Chae, HZ
通讯作者：
Chae, HZ
过氧化氢激活氧化还原传感器 Pap1 需要调节细胞内氧化剂浓度
影响因子：
3.6
作者：
Ana Vivancos;Esther A. Castillo;N. Jones;J. Ayté;E. Hidalgo
通讯作者：
E. Hidalgo