IMMUNE-MECHANISMS IN AUTOIMMUNE OCULAR DISEASE
IMMUNE-MECHANISMS IN AUTOIMMUNE OCULAR DISEASE
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DOI：
10.1038/eye.1988.51
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发表时间：
1988-01-01
期刊：
影响因子：
3.9
通讯作者：
LIGHTMAN, S
中科院分区：
文献类型：
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作者：
LIGHTMAN, S
非免疫细胞异常表达II类MHC抗原(Ia)被认为是自身免疫性疾病发病过程中的重要机制，包括影响眼睛的疾病。提示循环中的自身反应性T细胞通过靶器官的血管内皮细胞异常表达Ia抗原而被导向靶器官。这项研究使用了两种不同的严重眼部炎症模型，分别由S抗原或牛血清白蛋白诱导，验证了这一假说。在S抗原诱导的炎症反应中，视网膜血管内皮细胞变为Ia+，而在牛血清白蛋白诱导的炎症反应中，视网膜血管内皮细胞无变化。比较了两种眼部炎症中眼部抗原(S抗原)特异的T细胞系TH在眼内的积聚情况，并与非眼部抗原(PPD)特异性T细胞系THP的积聚进行了比较。在S抗原诱导的炎症中，TH的积聚比THP大得多，而在牛血清白蛋白诱导的炎症中，两种T细胞株的积聚程度相同，但比未发炎的眼更多。这些结果表明，当视网膜血管内皮细胞在炎症过程中表达Ia抗原时，自身反应性T细胞将特异性地保留在眼睛中，并持续自身免疫破坏过程。
Aberrant expression of Class II MHC antigens (Ia) by non-immune cells is considered to be an important mechanism in the pathogenesis of autoimmune disease processes including those affecting the eye. It is suggested that circulating autoreactive T-cells are directed to their target organ as a result of aberrant expression of Ia antigens by the vascular endothelium of that organ. This hypothesis was tested in this study using two different models of severe ocular inflammation, induced by either S-antigen or bovine serum albumin (BSA). The retinal vascular endothelium becomes Ia+ in S-antigen induced inflammation but not in inflammation induced by BSA. The accumulation in the eye of a T-cell line, ThS, specific for an ocular antigen (S-antigen), was compared in the two types of ocular inflammation and compared to that of another T-cell line, ThP, specific for a non-ocular antigen (PPD). In S-antigen induced inflammation, there was much greater accumulation of ThS than ThP whereas in BSA induced inflammation, both T-cell lines accumulated to the same extent but more than in uninflamed eyes. These results suggest that when the retinal vascular endothelium expresses Ia antigens during an inflammatory process, autoreactive T-cells will be specifically retained in the eye as a result of this and perpetuate the autoimmune destructive process.