C-reactive protein levels and sleep disturbances:: Observations based on the northern Finland 1966 birth cohort study
C-reactive protein levels and sleep disturbances:: Observations based on the northern Finland 1966 birth cohort study
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DOI：
10.1097/psy.0b013e318157cb96
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发表时间：
2007-10-01
影响因子：
3.3
通讯作者：
Timonen, Markku
中科院分区：
文献类型：
--
作者：
Liukkonen, Timo;Raesaenen, Pirkko;Timonen, Markku
目的：在人群水平上探讨C反应蛋白（CRP）水平与睡眠障碍的关系。已发现CRP水平升高伴随睡眠障碍，但迄今为止的证据仅来自有限的临床和实验研究;缺乏流行病学研究。方法：我们利用了北方芬兰1966年出生队列，其参与者被随访至31岁。采用超敏C反应蛋白（hs-CRP）酶免疫分析法测定4011例受试者的hs-CRP浓度。自我报告的睡眠障碍从I（没有问题）到5（严重障碍）。结果如下：在调整混杂因素后，多变量分析显示，在睡眠障碍类别“中度、相当大和严重”（即，自我报告的睡眠障碍等级为3、4或5）的男性比“无”睡眠障碍的男性高18%（18.2%，95%置信区间3.0%至36.3%）。在女性中，hs-CRP水平在不同的睡眠障碍类别之间没有显着差异。结论：我们的研究结果支持了这一假设，即男性中重度睡眠障碍与流行病学水平上CRP水平的轻微升高有关。需要进一步的调查，看看我们的结果是否可以在其他数据库中复制。
Objective: To investigate whether sleep disturbances are associated with C-reactive protein (CRP) levels at the population level. Elevated CRP levels have been found to accompany sleep disturbances, but evidence so far comes only from limited clinical and experimental studies; epidemiological studies are lacking. Methods: We utilized the Northern Finland 1966 Birth Cohort, whose participants have been followed up to the age of 31 years. The hs-enzyme immunoassay method was used to measure highly sensitive-CRP (hs-CRP) concentrations (4011 participants). Self-reported sleep disturbances were ranked from I (no problem) to 5 (severe disturbances). Results: Multivariate analyses, after adjusting for confounders, revealed that hs-CRP levels in men in the sleep disturbance category "moderate, considerable and severe" (i.e., self-reported sleep disturbances rated 3, 4, or 5), were > 18% (18.2%, 95% Confidence Interval 3.0% to 36.3%) higher than those in men with "no" sleep disturbance. In women, hs-CRP levels did not significantly differ between different sleep disturbance categories. Conclusions: Our results support the hypothesis that moderate-to-severe sleep disturbances in men are associated with slightly increased CRP levels at the epidemiological level. Further investigations are called for to see whether our results can be replicated in other databases.