Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity.
Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity.
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DOI：
10.2147/jir.s318327
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发表时间：
2021
影响因子：
4.5
通讯作者：
Yu M
中科院分区：
文献类型：
--
作者：
Yang S;Yu M
杯状细胞及其分泌的粘液是一个重要的屏障，防止病原体侵入粘膜引起肠道炎症。关于杯状细胞和粘液的观点已经改变，目前的证据表明它们不是被动的，而是在维持肠道免疫和粘膜稳态方面发挥积极作用。杯状细胞可以获得管腔抗原，将其呈递给潜在的抗原呈递细胞（APC），诱导适应性免疫反应。多种免疫调节因子可促进杯状细胞的分化成熟和粘蛋白的分泌。杯状细胞的异常增殖和分化，以及粘蛋白合成和分泌的不足，导致肠粘膜屏障功能障碍。本文综述了调节杯状细胞增殖和分化以及控制粘蛋白合成和分泌的信号通路的广泛概述，以阐明改变这些通路如何影响杯状细胞的功能。此外，粘蛋白和杯状细胞之间的相互作用在肠粘膜免疫学的描述。因此，说明了杯状细胞和粘液在促进肠道防御和稳态方面的贡献，同时阐明了所涉及的调节机制可能允许开发用于肠道疾病的新治疗策略。
Goblet cells and the mucus they secrete serve as an important barrier, preventing pathogens from invading the mucosa to cause intestinal inflammation. The perspective regarding goblet cells and mucus has changed, with current evidence suggesting that they are not passive but play a positive role in maintaining intestinal tract immunity and mucosal homeostasis. Goblet cells could obtain luminal antigens, presenting them to the underlying antigen-presenting cells (APCs) that induces adaptive immune responses. Various immunomodulatory factors can promote the differentiation and maturation of goblet cells, and the secretion of mucin. The abnormal proliferation and differentiation of goblet cells, as well as the deficiency synthesis and secretion of mucins, result in intestinal mucosal barrier dysfunction. This review provides an extensive outline of the signaling pathways that regulate goblet cell proliferation and differentiation and control mucins synthesis and secretion to elucidate how altering these pathways affects goblet functionality. Furthermore, the interaction between mucins and goblet cells in intestinal mucosal immunology is described. Therefore, the contribution of goblet cells and mucus in promoting gut defense and homeostasis is illustrated, while clarifying the regulatory mechanisms involved may allow the development of new therapeutic strategies for intestinal disorders.