31P‐{1H} echo‐planar spectroscopic imaging of the human brain in vivo
31P‐{1H} echo‐planar spectroscopic imaging of the human brain in vivo
复制标题
人脑活体31P-{1H}回波平面光谱成像
DOI：
10.1002/mrm.21192
复制
发表时间：
2007
影响因子：
3.3
通讯作者：
P. Bachert
中科院分区：
文献类型：
--
作者：
M. Ulrich;T. Wokrina;G. Ende;M. Lang;P. Bachert
回波平面光谱成像(EPSI)是最快的光谱成像方法之一。它已被应用于活体人脑的核磁共振波谱(MRS)研究。然而，据我们所知，检测31P核以监测含磷神经代谢物的EPSI尚未被考虑。在临床1.5T全身磁共振断层扫描仪上，实现了8种不同的31P-1H EPSI序列，其频谱宽度从313 Hz到2.27 kHz不等。序列版本利用异核Overhaser效应(NOE)来增强31P信号。在模型解的实验中观察到的灵敏度与理论预测符合得很好。对健康志愿者(N=16)进行的活体测量表明，在人脑中进行二维(2D)31P-{1H}EPSI是可行的，该技术能够快速获取分辨率良好的局域光谱。医学杂志57：784-790,2007。©2007 Wiley-Liss Inc.
Echo‐planar spectroscopic imaging (EPSI) is one of the fastest spectroscopic imaging (SI) methods. It has been applied to 1H MR spectroscopy (MRS) studies of the human brain in vivo. However, to our knowledge, EPSI with detection of the 31P nucleus to monitor phosphorus‐containing neurometabolites has not yet been considered. In this work, eight different 31P‐{1H} EPSI sequence versions with spectral widths ranging from 313 Hz to 2.27 kHz were implemented on a clinical 1.5T whole‐body MR tomograph. The sequence versions utilized the heteronuclear nuclear Overhauser effect (NOE) for 31P signal enhancement. The sensitivity observed in experiments with model solutions was in good agreement with theoretical predictions. In vivo measurements performed on healthy volunteers (N = 16) demonstrated the feasibility of performing two‐dimensional (2D) 31P‐{1H} EPSI in the human brain, and the technique enabled fast acquisition of well‐resolved localized spectra. Magn Reson Med 57:784–790, 2007. © 2007 Wiley‐Liss, Inc.
影响因子：
19.7
作者：
MAUDSLEY, AA;HILAL, SK;WITTEKOEK, S
通讯作者：
WITTEKOEK, S
光谱成像显示和分析。
影响因子：
2.5
作者：
Maudsley,AA;Lin,E;Weiner,MW
通讯作者：
Weiner,MW
影响因子：
19.7
作者：
POSSE, S;DECARLI, C;LEBIHAN, D
通讯作者：
LEBIHAN, D