Circadian variation in allergen and nonspecific bronchial responsiveness in asthma
Circadian variation in allergen and nonspecific bronchial responsiveness in asthma
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DOI：
10.3109/07420529908998732
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发表时间：
1999-01-01
影响因子：
2.8
通讯作者：
Jarjour, NN
中科院分区：
文献类型：
--
作者：
Jarjour, NN
在大多数患者中，哮喘的加重在夜间比白天更频繁。已经提出了许多假说来解释哮喘中的这种变化。哮喘患者的呼吸道具有异常程度的炎症和对非特异性和特异性挑战的高反应性。对哮喘儿童和成人的研究表明，呼吸道对组胺、乙酰胆碱、乙酰胆碱、生理盐水和屋尘螨的刺激反应有明显的昼夜节律性。综上所述，这些调查结果表明，与中午和下午进行的测试相比，夜间和夜间测试后呼吸道对这些药物的高反应性更加深刻和持续时间更长。支气管对冷干空气过度换气反应的时间模式不同。下午，航空公司对这一挑战的反应最快。气道高反应性昼夜节律的幅度似乎与肺功能昼夜节律的幅度相关；支气管反应性的昼夜差异越大，流量的昼夜差异越大。
In a majority of patients, exacerbations of asthma occur more frequently during the night than day. Many hypotheses have been proposed to explain such Variation in asthma. The airways of asthmatic persons are characterized by an abnormal degree of inflammation and bronchial hyperresponsiveness to both nonspecific and specific challenges. Studies of both children and adults with asthma document marked circadian rhythmicity in the response of airways to bronchial challenges with histamine, methacholine, acetylcholine, saline, and house dust mite. Taken together, the findings of these investigations indicate that the hyperreactivity of airways to these agents is more profound and prolonged following evening and overnight tests compared to tests conducted in the midday and afternoon. The temporal pattern in bronchial response to the hyperventilation of cold dry air is different. The hyperresponsiveness of airways to this challenge is greatest in the afternoon. The amplitude of the circadian rhythm in airway hyperreactivity seems to be correlated to the amplitude of the circadian rhythm of pulmonary function; the greater the day-night difference in bronchial reactivity is, the greater is the day-night difference in flow rates.