Comparison of plan optimization for single and dual volumetric-modulated arc therapy versus intensity-modulated radiation therapy during post-mastectomy regional irradiation
Comparison of plan optimization for single and dual volumetric-modulated arc therapy versus intensity-modulated radiation therapy during post-mastectomy regional irradiation
复制标题
乳房切除术后区域照射期间单、双容量调制弧疗法与调强放射疗法的计划优化比较
DOI：
10.3892/ol.2016.4376
复制
发表时间：
2016-05-01
期刊：
影响因子：
2.9
通讯作者：
Sun, Jian-Guo
中科院分区：
文献类型：
--
作者：
Zhao, Li-Rong;Zhou, Yi-Bing;Sun, Jian-Guo
本研究的目的是探讨单弧（1ARC）和双弧（2ARC）调强放射治疗（IMRT）和容积调强放射治疗（VMAT），并评价乳腺癌术后局部照射的质量和输送效率。本研究共纳入24例乳腺切除术后需要局部放疗的女性患者，为每位患者设计了1ARC、2ARC和IMRT计划。通过计算同侧肺、双肺、对侧乳腺、心脏和脊髓的均匀性指数（HI）、符合性指数（CI）和比体积剂量来评价这些计划的质量。对于这些计划的交付效率，评价了总治疗时间（TTT）和监测单元（MU）的数量。1ARC和2ARC VMAT计划的HI和CI显著优于IMRT。剂量-体积直方图分析显示，1ARC和2ARC VMAT对同侧肺、双肺、对侧乳腺、心脏和脊髓的特定体积剂量高于IMRT（P
The aim of the present study was to investigate volumetric-modulated arc therapy (VMAT) with single arc (1ARC) and dual arc (2ARC), and intensity-modulated radiation therapy (IMRT), and to evaluate the quality and delivery efficiency of post-mastectomy regional irradiation. A total of 24 female patients who required post-mastectomy regional irradiation were enrolled into the current study, and 1ARC, 2ARC and IMRT plans were designed for each individual patient. The quality of these plans was evaluated by calculating the homogeneity index (HI), conformity index (CI) and specific volume dose to the ipsilateral lung, double lungs, contralateral breast, heart and spinal cord. For the delivery efficiency of these plans, the total treatment time (TTT) and the number of monitor units (MUs) were evaluated. The 1ARC and 2ARC VMAT plans exhibited significantly better HIs and CIs than IMRT. For dose-volume histogram analysis, 1ARC and 2ARC VMAT spared a more specific volume dose to the ipsilateral lung, double lungs, contralateral breast, heart and spinal cord than IMRT (P