The Wnt/β-catenin pathway:: master regulator of liver zonation?
The Wnt/β-catenin pathway:: master regulator of liver zonation?
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DOI：
10.1002/bies.20485
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发表时间：
2006-11-01
期刊：
影响因子：
4
通讯作者：
Tosh, David
中科院分区：
文献类型：
--
作者：
Burke, Zoe D.;Tosh, David
肝脏有两个系统来清除氨--尿素循环和谷氨酰胺合成酶。这些系统以互补的方式在两个不同的肝细胞群体中表达，称为门静脉周围细胞和静脉周围细胞。肝病学中尚未解决的问题之一是阐明氨解毒细胞异质性诱导和维持的分子机制。现在有一个潜在的分子解释尿素循环和谷氨酰胺合成酶的分区的基础上Wnt/β-连环蛋白途径。
The liver contains two systems for the removal of ammonia-the urea cycle and the enzyme glutamine synthetase. These systems are expressed in a complementary fashion in two distinct populations of hepatocytes, referred to as periportal and perivenous cells. One of the unresolved problems in hepatology has been to elucidate the molecular mechanisms responsible for induction and maintenance of the cellular heterogeneity for ammonia detoxification. There is now a potential molecular explanation for the zonation of the urea cycle and glutamine synthetase based on the Wnt/beta-catenin pathway.