Promoting effect of sodium o-phenylphenate and o-phenylphenol on two-stage urinary bladder carcinogenesis in rats.
Promoting effect of sodium o-phenylphenate and o-phenylphenol on two-stage urinary bladder carcinogenesis in rats.
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邻苯基苯酚钠和邻苯基苯酚对大鼠两期膀胱癌的促进作用。
DOI：
10.20772/cancersci1959.74.5_625
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
N. Ito
中科院分区：
文献类型：
--
作者：
S. Fukushima;Y. Kurata;M. Shibata;E. Ikawa;N. Ito
本文观察了邻苯基酚钠（OPP-Na）和邻苯基酚（OPP-Na）对N-丁基-N-（4-羟丁基）亚硝胺（BBN）诱发的F344大鼠膀胱癌的影响。在饮食中给予2.0% OPP-Na显著增加了0.01% BBN预处理大鼠膀胱癌前病变（乳头状或结节性增生; PN增生）的发生率和每10 cm基底膜的数量，以及0.05% BBN预处理组膀胱乳头状瘤和膀胱癌的发生率和数量。此外，在未预先开始BBN的情况下，用2.0% OPP-Na治疗诱导PN增生、乳头状瘤和癌症。相比之下，BBN后膀胱病变的发生率似乎仅略有增加，其影响无统计学意义。它也没有诱发膀胱肿瘤。这些结果提供了证据，OPP-Na对膀胱具有促进活性，而OPP-Na对膀胱没有促进活性。此外，OPP-Na可能是大鼠膀胱中的完全致癌物的可能性值得考虑。
The effects of sodium o-phenylphenate (OPP-Na) and o-phenylphenol (OPP) on 2-stage urinary bladder carcinogenesis in F344 rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) at levels of 0.01 or 0.05% in drinking water were investigated. Administration of 2.0% OPP-Na in the diet significantly increased both the incidence and the number per 10 cm of basement membrane of preneoplastic lesions (papillary or nodular hyperplasia; PN hyperplasia) of the urinary bladder in rats pretreated with 0.01% BBN, and also those of papilloma and cancer of the urinary bladder in the group pretreated with 0.05% BBN. Moreover, treatment with 2.0% OPP-Na, without prior BBN initiation, induced PN hyperplasia, papilloma and cancer. In contrast, OPP appeared to produce only a slight increase in the incidence of urinary bladder lesions following BBN, and its effect was not statistically significant. It also did not induce tumors of the urinary bladder. These results provide evidence that OPP-Na has promoting activity toward the urinary bladder while OPP does not. Moreover, the possibility that OPP-Na may be a complete carcinogen in the rat urinary bladder deserves consideration.