Sex Moderates the Impact of Diagnosis and Amyloid PET Positivity on Hippocampal Subfield Volume.
Sex Moderates the Impact of Diagnosis and Amyloid PET Positivity on Hippocampal Subfield Volume.
复制标题
DOI：
10.3233/jad-180028
复制
发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Caldwell JZK;Berg JL;Shan G;Cummings JL;Banks SJ;Alzheimer’s Disease Neuroimaging Initiative
我们研究了性别和诊断对阳性florbetapir正电子发射断层扫描（PET）淀粉样蛋白-β（Aβ）扫描（A+）对526名正常对照（NC）和早期轻度认知障碍（eMCI）参与者海马子域体积的影响的调节作用，这些参与者来自阿尔茨海默病神经成像倡议（ADNI 2; ADNI-GO）。回归适度模型显示，女性-但不是男性-NC指定没有显示下托体积减少，尽管A+。在eMCI阶段，A+对性别有害。结果是显着的，而占年龄的影响，认知在筛选，教育和APOE 4载体状态。这些发现表明，A+女性对阿尔茨海默病相关的淀粉样蛋白负荷具有早期神经抵抗力。
We examined moderation effects of sex and diagnosis on the effect of positive florbetapir positron emission tomography (PET) amyloid-β (Aβ) scan (A+) on hippocampus subfield volumes in 526 normal control (NC) and early mild cognitive impairment (eMCI) participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI2; ADNI-GO). Regression moderation models showed that women— but not men— with NC designation did not show reduced subiculum volumes despite A+. At the eMCI stage, A+ was detrimental across sexes. Findings were significant while accounting for the effects of age, cognition at screening, education, and APOE4 carrier status. These findings suggest that women with A+ have early neural resistance to Alzheimer’s disease-related amyloid burden.