TOXOPLASMA GONDII INFECTION AND DEPRESSION: A CASE-CONTROL SEROPREVALENCE STUDY
TOXOPLASMA GONDII INFECTION AND DEPRESSION: A CASE-CONTROL SEROPREVALENCE STUDY
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DOI：
10.1556/1886.2016.00010
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发表时间：
2016-06-01
影响因子：
2.2
通讯作者：
Liesenfeld, Oliver
中科院分区：
文献类型：
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作者：
Alvarado-Esquivel, Cosme;Francisco Sanchez-Anguiano, Luis;Liesenfeld, Oliver
我们在精神病患者和无抑郁症的对照受试者样本中评估了弓形虫感染与抑郁症的关联。我们对墨西哥杜兰戈市一家公立精神病医院就诊的 89 名抑郁症患者和来自同一城市一般人群的 356 名无抑郁症对照受试者进行了一项年龄和性别匹配的病例对照研究。使用酶联免疫分析测试参与者是否存在抗弓形虫 IgG 和 IgM 抗体。抗T。在 89 例病例中的 11 例（12.4%）和 356 例对照中的 22 例（6.2%）中发现了弓形虫 IgG 抗体（OR = 2.14；95% CI：1.00-4.59；P = 0.04）。抗T。 21 种抗 T 弓形虫 IgM 抗体在 4 种（19%）中被发现。弓形虫 IgG 血清阳性对照，但 11 抗 T 抗体未见阳性。弓形虫 IgG 血清阳性病例（P = 0.27）。 30岁及以下患者的弓形虫感染血清阳性率显着高于同年龄组的对照组（P = 0.001）。本研究的结果表明弓形虫感染与抑郁症之间存在潜在关联。应该进行进一步的研究来证实我们的结果并确定年轻抑郁症患者中弓形虫的流行病学。
We assessed the association of Toxoplasma gondii infection and depression in a sample of psychiatric patients and control subjects without depression. We performed an age-and gender-matched case-control study of 89 patients suffering from depression attended in a public psychiatric hospital in Durango City, Mexico and 356 control subjects without depression from the general population of the same city. Participants were tested for the presence of anti-Toxoplasma IgG and IgM antibodies using enzymelinked immunoassays. Anti-T. gondii IgG antibodies were found in 11 (12.4%) of the 89 cases and in 22 (6.2%) of the 356 controls (OR = 2.14; 95% CI: 1.00-4.59; P = 0.04). Anti-T. gondii IgM antibodies were found in four (19%) of 21 anti-T. gondii IgG seropositive controls but not in 11 anti-T. gondii IgG seropositive cases (P = 0.27). Patients aged 30 years old and younger had a significantly higher seroprevalence of T. gondii infection than controls of the same age group (P = 0.001). Results of the present study suggest a potential association between T. gondii infection and depression. Furthers studies to confirm our results and to determine the epidemiology of T. gondii in young depressed patients should be conducted.