Anti-Proteus activity of some South African medicinal plants: their potential for the prevention of rheumatoid arthritis
Anti-Proteus activity of some South African medicinal plants: their potential for the prevention of rheumatoid arthritis
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DOI：
10.1007/s10787-013-0179-3
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发表时间：
2014-02-01
影响因子：
5.8
通讯作者：
van Vuuren, S. F.
中科院分区：
文献类型：
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作者：
Cock, I. E.;van Vuuren, S. F.
在非洲传统医学中，各种各样的草药被用来治疗类风湿性关节炎（RA）和炎症。研究了从13种南非植物中提取的34种提取物，这些提取物具有民族植物学上用于治疗炎症的历史，以研究它们控制两种引发RA的微生物（奇异变形杆菌和寻常变形杆菌）的能力。其中29种提取物（85.3%）对奇异假单胞菌的生长有抑制作用，23种提取物（67.7%）对寻常假单胞菌的生长有抑制作用。毛竹、黄皮草、绿花天竺葵、斜梭梭、山茱萸叶和树皮、毛茱萸、白芷、白茱萸树皮和白茱萸叶水提物的甲醇和水提物均为有效的Proteus抑制剂，其MIC值< 2000 μ g/ml。采用反相高效液相色谱法和紫外-可见光谱法检测白藜芦醇的存在。只有白藜芦醇和白藜芦醇提取物中含有白藜芦醇，表明白藜芦醇不是本文报道的抗变形杆菌作用的原因。所有具有变形杆菌抑制活性的提取物在青蒿生物试验中均为无毒或低毒。这些提取物的低毒性及其对变形杆菌的抑制生物活性表明它们具有阻断类风湿关节炎发病的潜力。
A wide variety of herbal remedies are used in traditional African medicine to treat rheumatoid arthritis (RA) and inflammation. Thirty-four extracts from 13 South African plant species with a history of ethnobotanical usage in the treatment of inflammation were investigated for their ability to control two microbial triggers for RA (Proteus mirabilis and Proteus vulgaris). Twenty-nine of the extracts (85.3 %) inhibited the growth of P. mirabilis and 23 of them tested (67.7 %) inhibited the growth of P. vulgaris. Methanol and water extracts of Carpobrotus edulis, Lippia javanica, Pelargonium viridflorum, Ptaeroxylon obliquum, Syzygium cordatum leaf and bark, Terminalia pruinoides, Terminalia sericea, Warburgia salutaris bark and an aqueous extract of W. salutaris leaf were effective Proteus inhibitors, with MIC values < 2,000 mu g/ml. The most potent extracts were examined by Reverse phase high performance liquid chromatography and UV-Vis spectroscopy for the presence of resveratrol. Only extracts from T. pruinoides and T. sericea contained resveratrol, indicating that it was not responsible for the anti-Proteus properties reported here. All extracts with Proteus inhibitory activity were also either non-toxic, or of low toxicity in the Artemia nauplii bioassay. The low toxicity of these extracts and their inhibitory bioactivity against Proteus spp. indicate their potential for blocking the onset of rheumatoid arthritis.