Fabrication of Pure Nanodrugs of Podophyllotoxin Dimer and Their Anticancer Activity
Fabrication of Pure Nanodrugs of Podophyllotoxin Dimer and Their Anticancer Activity
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DOI：
10.1246/cl.130224
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发表时间：
2013-08-05
影响因子：
1.6
通讯作者：
Kasai, Hitoshi
中科院分区：
文献类型：
--
作者：
Ikuta, Yoshikazu;Koseki, Yoshitaka;Kasai, Hitoshi
水不溶性生物活性化合物的药物纳米粒在下一代药物递送系统（DDS）中具有潜在的应用前景。作为这种纳米颗粒的一个例子，合成了二聚鬼臼毒素（PPT），并通过再沉淀法制备了PPT纳米颗粒。据发现，这些纳米颗粒显示出比依托泊苷（PPT的类似物）高得多的癌细胞毒性。
Drug nanoparticles of water-insoluble bioactive compounds are potentially applicable in next-generation drug delivery systems (DDSs). As an example of such nanoparticles, the dimeric podophyllotoxin (PPT) was synthesized, and PPT nanoparticles were fabricated by the reprecipitation method. It was found that these nanoparticles show much higher cytotoxity for cancer cells as compared to etoposide, which is an analog of PPT.