Association of delayed chronotype with allergic diseases in primary school children
Association of delayed chronotype with allergic diseases in primary school children
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小学生睡眠时间延迟型与过敏性疾病的关系
DOI：
10.1080/07420528.2022.2040527
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发表时间：
2022-03-06
影响因子：
2.8
通讯作者：
Li, Shenghui
中科院分区：
文献类型：
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作者：
Chen, Yiting;Zhao, Anda;Li, Shenghui
摘要探讨小学生的睡眠中点（包括周末和工作日）和睡眠时间类型与过敏性疾病（特别是哮喘、过敏性鼻炎和湿疹）的关系。在这项横断面研究中，我们评估了10409名7至12岁的儿童（平均9.21 ± 1.51岁;男性52.2%）。每种过敏性疾病定义为既有确诊疾病又有当前症状的儿童，参照组描述为没有任何过敏症状的儿童。睡眠持续时间和睡眠中期时间是根据报告的睡眠时间计算的。时间类型是通过在空闲的日子里校正过睡的中间睡眠时间来确定的。过敏儿童睡眠时间较短，睡眠偏好较晚。较晚的每周睡眠中点与过敏的几率较高有关，而较晚的工作日中点的几率甚至高于周末的中点。关于生理时钟类型，越晚的生理时钟类型，患过敏性鼻炎和湿疹的几率越高。此外，工作日晚睡中点对过敏的影响更强，因为睡眠较少的参与者（哮喘：aOR，1.62，95 CI %，1.25 -2.10，p < .001;过敏性鼻炎：aOR，2.12，95 CI %，1.68 -2.67，p < .001;湿疹：aOR，1.94，95 CI %，1.52 -2.48，p < .001）。此外，慢性型与过敏性鼻炎的关联被二手烟暴露所混淆。我们的研究发现了时间型与三种过敏性疾病的几率之间的关联，希望提高睡眠健康意识，特别是在患有过敏性疾病的特定人群中，并描述了评估可改变的行为因素的重要性，如睡眠习惯，作为预防和治疗过敏性疾病的合理因素。
ABSTRACT To investigate the associations of sleep midpoint for both weekdays and weekends, and chronotype, with allergic diseases, specifically asthma, allergic rhinitis, and eczema in primary school children. In this cross-sectional study, we evaluated 10409 children between 7 and 12 years of age (mean 9.21 ± 1.51 years; male 52.2%). Each allergic disease was defined as children with both diagnosed disease and current symptoms, and the reference group was described as children without any allergic symptoms. Sleep durations and mid-sleep times were calculated by reported sleep timing. Chronotype was determined by mid-sleep time on free days corrected for oversleeping. Children with allergies have shorter sleep duration and later sleep preferences. Late weekly sleep midpoints were associated with higher odds of allergies, and the odds were even higher for later weekday midpoints than their weekend counterparts. Regarding chronotype, the more evening chronotype, the higher the odds of allergic rhinitis and eczema. Additionally, effect of weekday late sleep midpoint on allergies was stronger as the participants who slept less (asthma: aOR,1.62, 95 CI%,1.25–2.10, p < .001; allergic rhinitis: aOR,2.12, 95 CI%,1.68–2.67, p < .001; eczema: aOR, 1.94, 95 CI%,1.52–2.48, p < .001). Further, the associations of chronotype with allergic rhinitis were confounded by second-hand smoking exposure. Our study, which finds an association between chronotype and the odds of three allergic diseases, hopes to improve sleep health awareness, especially in the particular population with allergic diseases, and describes the importance of evaluating modifiable behavioral factors, such as sleep habits, as a plausible factor for the prevention and treatment of allergic diseases.