Fibrinolytic activity in the abdominal cavity of rats with faecal peritonitis
Fibrinolytic activity in the abdominal cavity of rats with faecal peritonitis
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DOI：
10.1002/bjs.1800810740
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发表时间：
1994-07
影响因子：
9.6
通讯作者：
H. Goor;J. Graaf;J. Grond;Willem Sluiter;J. V. Meer;V. Bom;R. Bleichrodt
中科院分区：
文献类型：
--
作者：
H. Goor;J. Graaf;J. Grond;Willem Sluiter;J. V. Meer;V. Bom;R. Bleichrodt
泛发性腹膜炎引起腹部纤维蛋白溶解活性降低，导致腹腔内纤维蛋白持续存在，随后发生粘连和脓肿形成。本研究测定了粪性腹膜炎大鼠腹腔液中组织型纤溶酶原激活物（tPA）和纤溶酶原激活物抑制物（派）的活性，并与腹膜损伤程度进行相关性分析，以确定纤溶功能下降的原因。tPA的活性在8天的研究期间较低，但腹膜炎大鼠高于对照组。在整个实验过程中，腹膜炎大鼠血浆派活性均显著高于对照组（P <0.001）。腹膜炎大鼠和对照组的腹膜损伤组织学体征相似。腹膜损伤程度与tPA或派活性无相关性。粪性腹膜炎大鼠腹腔液中派活性增高可能是腹腔纤溶功能降低的主要原因。tPA和派的活性可能不仅来源于间皮细胞，还可能来自其他来源。
Generalized peritonitis causes a reduction in abdominal fibrinolytic activity, resulting in persistence of intraabdominal fibrin with subsequent adhesion and abscess formation. The activities of tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI) were measured in the peritoneal fluid of rats with faecal peritonitis and correlated with the extent of peritoneal damage to determine the cause of decreased fibrinolysis. Activity of tPA was low during the study period of 8 days, but higher in rats with peritonitis than in controls. The activity of PAI in rats with peritonitis was significantly increased compared with that of controls during the whole study period (P < 0·001). Histological signs of damage to the peritoneum were similar in rats with peritonitis and controls. There was no correlation between the extent of peritoneal damage and tPA or PAI activity. The increased activity of PAI in the peritoneal fluid of rats with faecal peritonitis may be the main cause of reduced fibrinolysis in the abdominal cavity. Activities of tPA and PAI may originate not only from the mesothelium but from other sources.