The BvgS/BvgA phosphorelay system of pathogenic Bordetellae -: Structure, function and evolution
The BvgS/BvgA phosphorelay system of pathogenic Bordetellae -: Structure, function and evolution
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DOI：
10.1007/978-0-387-78885-2_10
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Gross, Roy
中科院分区：
文献类型：
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作者：
Beier, Dagmar;Gross, Roy
在博德特氏菌属中，几种重要的人类和动物病原体与百日咳博德特氏菌（百日咳的病原体）在医学上最相关。在这些细菌中，最重要的毒力因子（包括几种毒素、粘附素和定植因子）的表达由单一主调节双组分系统（BvgS/BvgA 系统）控制。该系统代表了复杂磷酸中继系统的范例，该系统介导微调的转录反应，导致感染过程的不同阶段毒力因子的表达水平不同。本章讨论了有关信号感知的最新知识以及由单一二组分系统控制的差异基因表达的分子基础。
In the genus Bordetella several important human and animal pathogens are classified with B.pertussis, the etiological agent of whooping cough, being medically the most relevant. In these bacteria expression of the most important virulence factors including several toxins, adhesins and colonization factors is controlled by a single master regulatory two-component system, the BvgS/BvgA system. Ihis system represents a paradigm of a complex phosphorelay system that mediates a fine-tuned transcriptional response resulting in different expression levels of virulence factors during different stages of the infection process. In this chapter the current knowledge about signal perception and the molecular basis of differential gene expression controlled by a single two-component system is discussed.