The association between age and nephrosclerosis on renal biopsy among healthy adults.
The association between age and nephrosclerosis on renal biopsy among healthy adults.
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DOI：
10.7326/0003-4819-152-9-201005040-00006
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发表时间：
2010-05-04
影响因子：
39.2
通讯作者：
Stegall MD
中科院分区：
文献类型：
--
作者：
Rule AD;Amer H;Cornell LD;Taler SJ;Cosio FG;Kremers WK;Textor SC;Stegall MD
慢性肾脏疾病随着年龄的增长而变得常见，肾活检的特征是肾小球硬化、肾小管萎缩、间质纤维化和动脉硬化。了解这些肾脏组织学异常的患病率是否随健康成人年龄的增长而增加，以及组织学检查结果是否可以通过肾功能或慢性肾脏疾病风险因素的年龄相关差异来解释。1999年至2009年马约诊所的横断面研究1203例成人活体肾脏供体，手术植入肾脏期间获得的肾皮质芯针活检和捐赠前获得的肾功能和风险因素的病历数据。肾硬化的患病率（两种或多种慢性组织学异常）为2.7%（95%置信区间：1.1-6.7%），30-39岁为16%（12-20%），40-49岁为28%（24-32%），50-59岁为44%（38-50%），年龄60-69岁为58%（47-67%），70-77岁为73%（43-90%）。校正肾功能和危险因素协变量不能解释年龄相关的肾硬化患病率增加。肾脏捐献者是根据健康状况选择的，缺乏一般人群中肾脏病理的谱或严重程度。肾功能和慢性肾脏疾病危险因素不能解释健康成人年龄和肾硬化之间的强相关性。国立卫生研究院，美国公共卫生服务。
Chronic kidney disease becomes common with age and is characterized on renal biopsy by global glomerulosclerosis, tubular atrophy, interstitial fibrosis, and arteriosclerosis. To see if the prevalence of these histological abnormalities in the kidney increases with age in healthy adults and whether histological findings are explained by age-related differences in kidney function or chronic kidney disease risk factors. Cross-sectional study Mayo Clinic from 1999 to 2009 1203 Adult living kidney donors Core needle biopsy of the renal cortex obtained during surgical implantation of the kidney and medical record data of kidney function and risk factors obtained prior to donation. The prevalence of nephrosclerosis (two or more chronic histological abnormalities) was 2.7% (95% CI: 1.1-6.7%) for ages 18-29 y, 16% (12-20%) for ages 30-39 y, 28% (24-32%) for ages 40-49 y, 44% (38-50%) for ages 50-59 y, 58% (47-67%) for ages 60-69 y, and 73% (43-90%) for ages 70-77 y. Adjustment for kidney function and risk factor covariates did not explain the age-related increase in the prevalence of nephrosclerosis. Kidney donors are selected for health and lack the spectrum or severity of renal pathology in the general population. Kidney function and chronic kidney disease risk factors fail to explain the strong association between age and nephrosclerosis in healthy adults. National Institutes of Health, US Public Health Service.
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