Dermal absorption of amorphous nanosilica particles after topical exposure for three days
Dermal absorption of amorphous nanosilica particles after topical exposure for three days
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DOI：
10.1691/ph.2012.1853
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发表时间：
2012-08-01
期刊：
影响因子：
1.6
通讯作者：
Tsutsumi, Y.
中科院分区：
文献类型：
--
作者：
Hirai, T.;Yoshikawa, T.;Tsutsumi, Y.
在小鼠中分析了直径为70 nm的分散良好的无定形纳米二氧化硅颗粒（nSP）的皮肤渗透和细胞定位。我们的研究结果表明，在局部暴露三天后，颗粒穿透皮肤屏障并被转运到淋巴结。这些发现强调了需要检查皮肤暴露于nSP后的生物学效应，以开发更安全的nSP使用方法。
The skin penetration and cellular localization of well-dispersed amorphous nanosilica particles (nSPs) with a diameter of 70 nm was analyzed in mice. Our results suggest that after topical exposure for three days the particles penetrate the skin barrier and are transported to the lymph nodes. These findings underscore the need to examine biological effects following dermal exposure to nSPs for the development of safer use of nSPs.