Myocardial T1 and T2 mapping at 3 T: reference values, influencing factors and implications.
Myocardial T1 and T2 mapping at 3 T: reference values, influencing factors and implications.
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心肌T1和T2映射在3 t：参考值，影响因素和含义。
DOI：
10.1186/1532-429x-15-53
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发表时间：
2013-06-18
期刊：
影响因子：
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通讯作者：
Schulz-Menger J
中科院分区：
文献类型：
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作者：
von Knobelsdorff-Brenkenhoff F;Prothmann M;Dieringer MA;Wassmuth R;Greiser A;Schwenke C;Niendorf T;Schulz-Menger J
使用心血管磁共振（CMR）绘制心肌T1和T2有希望改善组织表征和早期疾病检测。本研究旨在分析在3t时进行T1和T2映射的可行性，提供参考价值。60名健康志愿者（男/女各30名，年龄分别为20 - 39岁、40-59岁、60-80岁，各20名）在3 t处进行3张短轴切片左心室T1和T2定位，获取3张不同T2准备时间的单次稳态自由进动（SSFP）图像。T1定位采用改良的Look-Locker反演恢复技术，在注射钆造影剂前后使用11张单发SSFP图像。量化各切片、各心肌节段T1、T2弛豫时间。T2和T1（对比前/对比后）平均时间分别为：44.1 ms/1157.1 ms/427.3 ms（基线）、45.1 ms/1158.7 ms/411.2 ms（中间）、46.9 ms/1180.6 ms/399.7 ms（峰值）。T2和造影前T1由基底向尖端升高，造影后T1降低。相关的受试者间变异是明显的（T2/对比前T1/对比后T1的散点因子1.08/1.05/1.11）。T2和对比后T1受心率影响（p < 0.0001, p = 0.0020），对比前T1受年龄影响（p < 0.0001）。T2 （r = 0.95; r = 0.95）和T1 （r = 0.91; r = 0.93）的观察者间和观察者内一致性较高。T2图谱：97.7%的所有节段是诊断性的，2.3%被排除（敏感性伪影）。T1图（对比前/对比后）：91.6%/93.9%被诊断，8.4%/6.1%被排除（主要是易感伪象7.7%/3.2%）。提供特定CMR设置的心肌T2和T1参考值。T2和T1弛豫时间的高主体间变异性对诊断的影响需要进一步研究。
Myocardial T1 and T2 mapping using cardiovascular magnetic resonance (CMR) are promising to improve tissue characterization and early disease detection. This study aimed at analyzing the feasibility of T1 and T2 mapping at 3 T and providing reference values. Sixty healthy volunteers (30 males/females, each 20 from 20–39 years, 40–59 years, 60–80 years) underwent left-ventricular T1 and T2 mapping in 3 short-axis slices at 3 T. For T2 mapping, 3 single-shot steady-state free precession (SSFP) images with different T2 preparation times were acquired. For T1 mapping, modified Look-Locker inversion recovery technique with 11 single shot SSFP images was used before and after injection of gadolinium contrast. T1 and T2 relaxation times were quantified for each slice and each myocardial segment. Mean T2 and T1 (pre-/post-contrast) times were: 44.1 ms/1157.1 ms/427.3 ms (base), 45.1 ms/1158.7 ms/411.2 ms (middle), 46.9 ms/1180.6 ms/399.7 ms (apex). T2 and pre-contrast T1 increased from base to apex, post-contrast T1 decreased. Relevant inter-subject variability was apparent (scatter factor 1.08/1.05/1.11 for T2/pre-contrast T1/post-contrast T1). T2 and post-contrast T1 were influenced by heart rate (p < 0.0001, p = 0.0020), pre-contrast T1 by age (p < 0.0001). Inter- and intra-observer agreement of T2 (r = 0.95; r = 0.95) and T1 (r = 0.91; r = 0.93) were high. T2 maps: 97.7% of all segments were diagnostic and 2.3% were excluded (susceptibility artifact). T1 maps (pre-/post-contrast): 91.6%/93.9% were diagnostic, 8.4%/6.1% were excluded (predominantly susceptibility artifact 7.7%/3.2%). Myocardial T2 and T1 reference values for the specific CMR setting are provided. The diagnostic impact of the high inter-subject variability of T2 and T1 relaxation times requires further investigation.