Imaging of the pediatric airway using optical coherence tomography
Imaging of the pediatric airway using optical coherence tomography
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DOI：
10.1097/mlg.0b013e318145b306
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发表时间：
2007-12-01
期刊：
影响因子：
2.6
通讯作者：
Wong, Brian
中科院分区：
文献类型：
--
作者：
Ridgway, James Matthew;Ahuja, Gurpreet;Wong, Brian
目标：光学相干断层扫描 (OCT) 是一种成像方式，使用宽带光源在活组织 (8-20 gm) 中产生高分辨率横截面图像。对儿科气道中的正常、良性和病理组织进行了一项前瞻性研究，以评估 OCT 技术在表征儿科上呼吸消化道体内显微解剖学特征方面的效用。研究设计：前瞻性临床试验。材料和方法：15 名 1 至 17 岁的患者因各种气道疾病接受了外科内窥镜检查和 OCT。使用 1.3-μm 宽带光源以 1 Hz 的帧速率进行 OCT 成像，产生垂直和水平尺寸为 1.6 X 6 mm 的图像。上皮、固有层和独特的组织微观结构被可视化，然后使用数字测微法进行测量。将OCT图像与内窥镜摄影进行直接比较。结果：所有15例患者均进行了口腔、口咽、下咽和喉部的系统成像。确定的正常微观结构包括乳头、导管、腺体和血管，而病理状况包括成熟疤痕、肉芽组织、水肿、溃疡和乳头状瘤病的不同区域。内镜照片与OCT图像具有良好的相关性。结论：OCT能够获得小儿气道体内组织的高分辨率显微解剖图像。 OCT 可以清楚地识别上皮和固有层，同时提供正常和患病组织的详细结构信息。 OCT 是一种有前途的新兴成像方式，可用于当前的儿科患者群体。
Objectives: Optical coherence tomography (OCT) is an imaging modality that uses a broadband light source to produce high-resolution cross-sectional images in living tissue (8-20 gm). A prospective study of normal, benign, and pathologic tissues in the pediatric airway was conducted to assess the utility of OCT technology in characterizing the microanatomy of the pediatric upper aerodigestive tract in vivo.Study Design: Prospective clinical trial.Materials and Methods: Fifteen patients from 1 to 17 years of age underwent surgical endoscopy and OCT for various airway disorders. OCT imaging was performed at a frame rate of 1 Hz using a 1.3-mu m broadband light source to produce images 1.6 X 6 mm in vertical and horizontal dimensions. The epithelium, lamina propria, and unique tissue microstructures were visualized and then measured using digital micrometry. Direct comparison of OCT images with endoscopic photography was performed.Results: Systematic imaging of the oral cavity, oropharynx, hypopharynx, and larynx was performed in all 15 patients. Normal microstructures identified included papillae, ducts, glands, and vessels, whereas pathologic conditions included distinct zones of mature scar, granulation tissue, edema, ulceration, and papillomatosis. Endoscopic photographs were well correlated with OCT images.Conclusions: OCT is capable of obtaining highresolution microanatomy images of pediatric airway in vivo tissue. OCT clearly identifies the epithelium and lamina propria while providing detailed structural information on normal and diseased tissues. OCT is a promising emerging imaging modality for use in current pediatric patient populations.