Optimizing distortion product otoacoustic emission recordings in normal-hearing ears by adopting cochlear place-specific stimuli
Optimizing distortion product otoacoustic emission recordings in normal-hearing ears by adopting cochlear place-specific stimuli
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DOI：
10.1121/10.0013218
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发表时间：
2022-08-01
影响因子：
2.4
通讯作者：
Dhar, Sumitrajit
中科院分区：
文献类型：
--
作者：
Stiepan, Samantha;Goodman, Shawn S.;Dhar, Sumitrajit
畸变产物耳声发射（dpoae）提供了一个了解主动耳蜗过程的窗口，并已成为流行的临床和研究工具。dpoae通常使用具有固定呈现水平和频率比的刺激来记录，而不考虑测试频率。然而，这与耳蜗隔板从基部到顶点的力学特性变化是不一致的，后者赋予耳蜗行波特定的频率依赖的空间特性。因此，刺激音调之间的频率和电平特性也需要作为频率的函数进行调整，以保持它们之间的最佳交互作用。本研究的目的是建立一个由局部耳蜗力学指导的频率特异性测量方案。在一组听力正常的个体中探索了延伸至20kHz的宽刺激参数空间。产生最大2f(1)-f(2) DPOAE水平的刺激频率比随频率和刺激水平的变化而变化。具体来说，在一定刺激水平下，产生最大DPOAE水平的频率比随着频率的增加而减小。同样，在给定频率f(2)下，产生最大DPOAE水平的刺激频率比随着刺激水平的增加而变宽。这些结果证实并加强了我们目前对正常功能耳蜗中DPOAE产生的理解，并将我们的理解扩展到以前未检测过的更高频率。这些数据支持使用频率和水平特异性刺激频率比来最大化DPOAE的产生。
Distortion product otoacoustic emissions (DPOAEs) provide a window into active cochlear processes and have become a popular clinical and research tool. DPOAEs are commonly recorded using stimulus with fixed presentation levels and frequency ratio irrespective of the test frequency. However, this is inconsistent with the changing mechanical properties of the cochlear partition from the base to the apex that lend specific frequency-dependent spatial properties to the cochlear traveling wave. Therefore, the frequency and level characteristics between the stimulus tones should also need to be adjusted as a function of frequency to maintain optimal interaction between them. The goal of this investigation was to establish a frequency-specific measurement protocol guided by local cochlear mechanics. A broad stimulus parameter space extending up to 20kHz was explored in a group of normal-hearing individuals. The stimulus frequency ratio yielding the largest 2f(1)-f(2) DPOAE level changed as a function of frequency and stimulus level. Specifically, for a constant stimulus level, the frequency ratio producing the largest DPOAE level decreased with increasing frequency. Similarly, at a given f(2) frequency, the stimulus frequency ratio producing the largest DPOAE level became wider as stimulus level increased. These results confirm and strengthen our current understanding of DPOAE generation in the normally functioning cochlea and expand our understanding to previously unexamined higher frequencies. These data support the use of frequency- and level-specific stimulus frequency ratios to maximize DPOAE generation.