TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells.
TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells.
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DOI：
10.1084/jem.20091059
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发表时间：
2009-08-31
期刊：
影响因子：
--
通讯作者：
O'Garra A
中科院分区：
文献类型：
--
作者：
Kaiser F;Cook D;Papoutsopoulou S;Rajsbaum R;Wu X;Yang HT;Grant S;Ricciardi-Castagnoli P;Tsichlis PN;Ley SC;O'Garra A
Stimulation of Toll-like receptors (TLRs) on macrophages and dendritic cells (DCs) by pathogen-derived products induces the production of cytokines, which play an important role in immune responses. Here, we investigated the role of the TPL-2 signaling pathway in TLR induction of interferon-β (IFN-β) and interleukin-10 (IL-10) in these cell types. It has previously been suggested that IFN-β and IL-10 are coordinately regulated after TLR stimulation. However, in the absence of TPL-2 signaling, lipopolysaccharide (TLR4) and CpG (TLR9) stimulation resulted in increased production of IFN-β while decreasing IL-10 production by both macrophages and myeloid DCs. In contrast, CpG induction of both IFN-α and IFN-β by plasmacytoid DCs was decreased in the absence of TPL-2, although extracellular signal-regulated kinase (ERK) activation was blocked. Extracellular signal-related kinase–dependent negative regulation of IFN-β in macrophages was IL-10–independent, required protein synthesis, and was recapitulated in TPL-2–deficient myeloid DCs by retroviral transduction of the ERK-dependent transcription factor c-fos.
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影响因子：
30.5
作者：
通讯作者：
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影响因子：
30.5
作者：
Papoutsopoulou, Stamatia;Symons, Antony;Ley, Steven C.
通讯作者：
Ley, Steven C.
影响因子：
4.8
作者：
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Trzaskos, JM
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64.8
作者：
Oganesyan, G;Saha, SK;Cheng, GH
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Cheng, GH
影响因子：
4.4
作者：
Gohda, J;Matsumura, T;Inoue, J
通讯作者：
Inoue, J