Helicobacter pylori infection in patients with diabetes mellitus.
Helicobacter pylori infection in patients with diabetes mellitus.
复制标题
糖尿病患者的幽门螺杆菌感染。
DOI：
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
C. Stanciu
中科院分区：
文献类型：
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作者：
O. Stanciu;A. Trifan;C. Sfarti;C. Cojocariu;C. Stanciu
有关糖尿病患者中幽门螺杆菌（H. pylori）患病率的数据很少且存在争议。本研究的目的是评估糖尿病（DM）患者幽门螺杆菌感染的患病率，并评估细菌的存在是否与此类患者消化不良症状的严重程度和内镜检查结果相关。该研究涉及 42 名患有糖尿病和消化不良症状的患者（19 名男性，23 名女性；平均年龄 55 岁，范围 34-75 岁）。 16 名患者 (38%) 被归类为患有 1 型糖尿病，26 名患者 (62%) 被归类为患有 2 型糖尿病。所有患者均患有慢性消化不良，每位患者均完成了一份自我报告调查问卷，以获取有关上消化道症状的存在及其严重程度的信息。通过13C-尿素呼气试验（13C-UBT）确认幽门螺杆菌状态，糖尿病患者接受上消化道内镜检查。 26 名 (61.9%) DM 患者 13C-UBT 呈阳性。 1型和2型糖尿病患者的感染率没有统计学上的显着差异，幽门螺杆菌感染的患病率与已知的糖尿病病程无关。幽门螺杆菌阳性和幽门螺杆菌阴性糖尿病患者的症状评分没有显着差异，糖尿病患者的内镜检查结果与同一地区消化不良受试者的内镜检查结果处于同一范围。总之，幽门螺杆菌感染与糖尿病、糖尿病病程或糖尿病患者消化不良症状的严重程度无关。
Data concerning the prevalence of Helicobacter pylori (H. pylori) in diabetic patients are scanty and controversial. The aim of this study was to evaluate the prevalence of H. pylori infection in patients with diabetes mellitus (DM), and to assess whether the presence of bacterium was associated with severity of dyspeptic symptoms and endoscopic findings in such patients. The study involved 42 patients (19 men, 23 women; mean age 55 years, range 34-75 years) with DM and dyspeptic symptoms. Sixteen patients (38%) were classified as having type 1 diabetes and 26 (62%) patients as having type 2 diabetes. All patients had chronic dyspepsia, and each patient has completed a self-report questionnaire to obtain information concerning the presence and severity of upper gastrointestinal tract symptoms. H. pylori status was confirmed by 13C-urea breath test (13C-UBT), and diabetic patients underwent upper gastrointestinal endoscopy. Twenty-six (61.9%) of patients with DM were positive for 13C-UBT. There were no statistically significant differences in the infection rate between patients with type 1 and type 2 diabetes, and the prevalence of H. pylori infection was not associated with the known duration of diabetes. There was no significant difference in the symptoms score between H. pylori-positive and H. pylori-negative diabetic patients, and endoscopic findings in patients with DM were in the same range with those found in dyspeptic subjects from the same region. In conclusion, H. pylori infection is not associated with DM, duration of diabetes, or severity of dyspeptic symptoms in patients with DM.