Dietary patterns and asthma in the E3N study
Dietary patterns and asthma in the E3N study
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DOI：
10.1183/09031936.00130807
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发表时间：
2009-01
影响因子：
24.3
通讯作者：
R. Varraso;F. Kauffmann;B. Leynaert;N. Moual;M. Boutron‐Ruault;F. Clavel-Chapelon;I. Romieu
中科院分区：
文献类型：
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作者：
R. Varraso;F. Kauffmann;B. Leynaert;N. Moual;M. Boutron‐Ruault;F. Clavel-Chapelon;I. Romieu
本研究的目的是确定饮食模式，并调查其与哮喘发病率，目前的哮喘和频繁的哮喘急性发作的关系。饮食习惯和哮喘数据收集自大型E3 N研究（法国女性，主要是教师）。在2003年随访的54，672名女性中，2，634人报告了成年期哮喘，1，063人报告了当前哮喘，206人报告了频繁的哮喘发作（每周一次或多次），628人报告了1993年至2003年期间的哮喘发作。使用主成分分析，确定了三种饮食模式：“谨慎”模式（水果和蔬菜）;“西方”模式（比萨饼/咸馅饼，甜点和腌肉）;和“坚果和葡萄酒”模式。将模式评分分为三分位数，并比较三分位数之间哮喘的发病率和患病率。校正混杂因素后，未观察到饮食模式与哮喘发病率、既往哮喘或当前哮喘之间的相关性。西方模式与报告频繁哮喘发作的风险增加相关（最高与最低三分位比值比（OR）1.79，95%置信区间（CI）1.11-3.73）。坚果和葡萄酒模式的得分增加与报告频繁哮喘发作的风险降低相关（最高与最低三分位数OR 0.65，95%CI 0.31-0.96）。本研究的结果表明，整体饮食可能涉及频繁的哮喘急性发作，哮喘严重程度的一个方面。
The aim of the present study was to determine dietary patterns and investigate their association with asthma incidence, current asthma and frequent asthma exacerbations. Dietary habits and asthma data were collected from the large E3N study (of French females, mostly teachers). Of the 54,672 females followed-up in 2003, 2,634 reported ever-adulthood asthma, 1,063 reported current asthma, 206 reported frequent asthma attacks (one or more a week), and 628 reported asthma onset between 1993 and 2003. Using principal component analysis, three dietary patterns were identified: the “prudent” pattern (fruits and vegetables); the “Western” pattern (pizza/salty pies, dessert and cured meats); and the “nuts and wine” pattern. Pattern scores were categorised into tertiles, and the incidence and prevalence of asthma was compared between tertiles. After adjustment for confounders, no association of dietary patterns was observed with asthma incidence, ever-asthma or current asthma. The Western pattern was associated with an increased risk of reporting frequent asthma attacks (highest versus lowest tertile odds ratio (OR) 1.79, 95% confidence interval (CI) 1.11–3.73). Increasing scores of the nuts and wine pattern were associated with a decreased risk of reporting frequent asthma attacks (highest versus lowest tertile OR 0.65, 95% CI 0.31–0.96). The results of the present study suggest that overall diet could be involved in frequent asthma exacerbations, one aspect of asthma severity.