Precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity with a targetable and activatable fluorescent probe
Precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity with a targetable and activatable fluorescent probe
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通过使用可靶向且可激活的荧光探针实时监测硝基还原酶活性，对癌细胞中的线粒体进行精确成像
DOI：
10.1039/d0cc00494d
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发表时间：
2020-07-18
影响因子：
4.9
通讯作者：
Zhao, Chunchang
中科院分区：
文献类型：
--
作者：
Zhu, Ning;Xu, Ge;Zhao, Chunchang
开发了一种可激活的、可靶向于细胞的荧光探针。这种设计的探针显示出比率荧光和点亮近红外发射响应于硝基还原酶，实现精确成像的线粒体在癌细胞中的硝基还原酶活性的实时监测。
An activatable and mitochondrial-targetable fluorescent probe was developed. This designed probe showed ratiometric fluorescence and light-up near-infrared emission responsiveness to nitroreductase, achieving precise imaging of mitochondria in cancer cells by real-time monitoring of nitroreductase activity.