Molecular Markers of Anticancer Drug Resistance in Head and Neck Squamous Cell Carcinoma: A Literature Review.
Molecular Markers of Anticancer Drug Resistance in Head and Neck Squamous Cell Carcinoma: A Literature Review.
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DOI：
10.3390/cancers10100376
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发表时间：
2018-10-10
期刊：
影响因子：
5.2
通讯作者：
Bologna-Molina R
中科院分区：
文献类型：
--
作者：
López-Verdín S;Lavalle-Carrasco J;Carreón-Burciaga RG;Serafín-Higuera N;Molina-Frechero N;González-González R;Bologna-Molina R
本手稿提供了有关头颈鳞状细胞癌 (HNSCC) 肿瘤抵抗治疗中分子的文献更新。尽管头颈鳞状细胞癌的治疗已取得显着进步，但医生仍面临另一个挑战，即保留口腔功能，其中涉及使用多学科疗法，例如多种化疗 (CT) 和放疗 (RT)。设计个性化治疗方案需要研究与耐药性相关的基因。本综述概述了与 HNSCC 化疗耐药相关的分子，包括 ATP 结合盒转运蛋白 (ABC) 家族、核苷酸切除修复/碱基切除修复 (NER/BER) 酶复合物（通过交联和形成链内/链间化学物质，作用于伽马和紫外线辐射产生的非特异性 DNA 损伤） 加合物）、顺铂（一种引起 DNA 损伤并诱导细胞凋亡的化疗药物，这是一个悖论，因为其有效性取决于参与细胞凋亡信号通路的基因的完整性）和西妥昔单抗，包括对参与细胞周期的基因和赋予西妥昔单抗抗性的可能标记物增殖的讨论。
This manuscript provides an update to the literature on molecules with roles in tumor resistance therapy in head and neck squamous cell carcinoma (HNSCC). Although significant improvements have been made in the treatment for head and neck squamous cell carcinoma, physicians face yet another challenge—that of preserving oral functions, which involves the use of multidisciplinary therapies, such as multiple chemotherapies (CT) and radiotherapy (RT). Designing personalized therapeutic options requires the study of genes involved in drug resistance. This review provides an overview of the molecules that have been linked to resistance to chemotherapy in HNSCC, including the family of ATP-binding cassette transporters (ABCs), nucleotide excision repair/base excision repair (NER/BER) enzymatic complexes (which act on nonspecific DNA lesions generated by gamma and ultraviolet radiation by cross-linking and forming intra/interchain chemical adducts), cisplatin (a chemotherapeutic agent that causes DNA damage and induces apoptosis, which is a paradox because its effectiveness is based on the integrity of the genes involved in apoptotic signaling pathways), and cetuximab, including a discussion of the genes involved in the cell cycle and the proliferation of possible markers that confer resistance to cetuximab.
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针对与肿瘤相关的糖蛋白72的FAS配体（FASL）进行的人源化抗体选择性地表现出对较低的FASL/FAS比的口服癌细胞的细胞毒性作用。
影响因子：
5.7
作者：
Chien MH;Chang WM;Lee WJ;Chang YC;Lai TC;Chan DV;Sharma R;Lin YF;Hsiao M
通讯作者：
Hsiao M
影响因子：
20.3
作者：
Bellosillo, B;Villamor, N;Montserrat, E
通讯作者：
Montserrat, E
影响因子：
3.3
作者：
Ansell, Anna;Jedlinski, Adam;Roberg, Karin
通讯作者：
Roberg, Karin
影响因子：
2.9
作者：
Elias, Silvia Taveira;Borges, Gabriel Alvares;Guerra, Eliete Neves Silva
通讯作者：
Guerra, Eliete Neves Silva
影响因子：
158.5
作者：
Bonner, JA;Harari, PM;Ang, KK
通讯作者：
Ang, KK