An autosomal genome scan for loci influencing longitudinal burden of body mass index from childhood to young adulthood in white sibships: The Bogalusa Heart Study
An autosomal genome scan for loci influencing longitudinal burden of body mass index from childhood to young adulthood in white sibships: The Bogalusa Heart Study
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DOI：
10.1038/sj.ijo.0802610
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发表时间：
2004-04-01
影响因子：
4.9
通讯作者：
Berenson, GS
中科院分区：
文献类型：
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作者：
Chen, W;Li, S;Berenson, GS
目的：目的：探讨与肥胖性状（如体重指数（BMI））从儿童期到成年期的长期负担和趋势相关的遗传位点，设计：采用连续测量儿童期BMI的纵向研究（代表521个全同胞对和39个半同胞对）来自参加博加卢萨心脏研究的342个家庭。共分型357个微卫星标记，平均间距为9.0 cM，跨越22条常染色体。二次生长曲线是使用随机效应模型，根据从儿童到成年的BMI系列测量。BMI的连续变化是根据长期负荷（曲线下面积（AUC）除以随访年数）和长期趋势（增量AUC，计算为总AUC -基线AUC）来测量的。结果：长期测量的遗传性估计值为总AUC为0.78，增量AUC为0.43。在一个方差分量为基础的多点连锁分析与SOLAR，连锁BMI的长期措施上观察到染色体1，5，7，12，13和18。对于总AUC，12号染色体上110 cM处的LOD评分为3.0，7号染色体上26 cM处为2.9，52 cM处为2.4，5号染色体上126 cM处为2.2。对于增量AUC，12号染色体上26 cM处LOD评分为2.9，97 cM处为2.1，110 cM处为2.3，7号染色体上69 cM处为2.2，1号染色体上91 cM处为2.2，150 cM处为2.5，5号染色体上119 cM处为2.0，13号染色体上54 cM处为2.0，18号染色体上7 cM处为2.0。几个重要的肥胖相关候选基因位于区域或附近的标记显示positivelinking.CONCLUSION：连锁证据表明，在这项研究中发现的这些染色体上的区域可能窝藏遗传位点，影响从儿童期发展肥胖的倾向。
OBJECTIVE: To examine genetic loci linked to a long-term burden and trend of obesity traits, such as body mass index (BMI), from childhood to adulthood.DESIGN: Longitudinal study using serial measurements of BMI from childhood.SUBJECTS: A total of 782 unselected white siblings ( representing 521 full and 39 half sib-pairs) from 342 families enrolled in the Bogalusa Heart Study.MEASUREMENTS: A total of 357 microsatellite markers with an average spacing of 9.0 cM spanning the 22 autosomal chromosomes were typed. A quadratic growth curve was developed using a random effects model based on serial measurements of BMI from childhood to adulthood. The serial changes in BMI were measured in terms of long-term burden ( area under the curve (AUC) divided by follow-up years) and the long-term trend ( incremental AUC, calculated as total AUC - baseline AUC).RESULTS: Heritability estimates of long-term measures were 0.78 for total AUC and 0.43 for incremental AUC. In a variance-component-based multipoint linkage analysis with SOLAR, linkage to the long-term measures of BMI was observed on chromosomes 1, 5, 7, 12, 13 and 18. For total AUC, LOD scores were 3.0 at 110 cM on chromosome 12, 2.9 at 26 cM and 2.4 at 52 cM on chromosome 7, and 2.2 at 126 cM on chromosome 5. For incremental AUC, LOD scores were 2.9 at 26 cM, 2.1 at 97 cM and 2.3 at 110 cM on chromosome 12, 2.2 at 69 cM on chromosome 7, 2.2 at 91 cM and 2.5 at 150 cM on chromosome 1, 2.0 at 119 cM on chromosome 5, 2.0 at 54 cM on chromosome 13 and 2.0 at 7 cM on chromosome 18. Several important obesity-related candidate genes are located in the regions or near the markers showing positive linkage.CONCLUSION: Linkage evidence found in this study indicates that regions on these chromosomes might harbor genetic loci that affect the propensity to develop obesity from childhood.